DNA mismatch repair (MMR) is responsible for correcting errors formed during DNA
replication. DNA polymerase errors include base mismatches and extra helical nucleotides …

Accurate DNA replication and transcription elongation are crucial for preventing the
accumulation of unreplicated DNA and genomic instability. Cells have evolved multiple …

DNA mismatch repair detects and corrects mismatches introduced during DNA replication.
The protein MutS scans for mismatches and coordinates the repair cascade. During this …

RecA is central to maintaining genome integrity in bacterial cells. Despite the near-
ubiquitous conservation of RecA in eubacteria, the pathways that facilitate RecA loading and …

Bacterial MutS proteins are subdivided into two families, MutS1 and MutS2. MutS1 family
members recognize DNA replication errors during their participation in the well …

The sliding clamp enhances polymerase processivity and coordinates DNA replication with
other critical DNA processing events including translesion synthesis, Okazaki fragment …

Bacterial genomes contain an abundance of transposable insertion sequence (IS) elements
that are essential for genome evolution and fitness. Among them, IS 629 is present in most …

Hydroxyurea (HU) is classified as a ribonucleotide reductase (RNR) inhibitor and has been
widely used to stall DNA replication by depleting deoxyribonucleoside triphosphate (dNTP) …

Homologous recombination requires the coordinated effort of several proteins to complete
break resection, homologous pairing, and resolution of DNA crossover structures. RecN is a …

Akkermansia muciniphila has potential as a next-generation probiotic, but few previous
studies attempted to analyze its intraspecies population diversity. In this study, we performed …