Due to its genetic tractability and increasing wealth of accessible data, the yeast
Saccharomyces cerevisiae is a model system of choice for the study of the genetics …

Amphipathic helices (AHs), a secondary feature found in many proteins, are defined by their
structure and by the segregation of hydrophobic and polar residues between two faces of …

Although the transcriptome, proteome, and interactome of several eukaryotic model
organisms have been described in detail, lipidomes remain relatively uncharacterized …

The endoplasmic reticulum (ER) consists of the nuclear envelope and a peripheral network
of tubules and membrane sheets. The tubules are shaped by the curvature-stabilizing …

Phospholipid and nucleotide syntheses are fundamental metabolic processes in eukaryotic
organisms, with their dysregulation implicated in various disease states. Despite their …

Cells constantly adjust the sizes and shapes of their organelles according to need. In this
study, we examine endoplasmic reticulum (ER) membrane expansion during the unfolded …

Lipid droplets (LDs) are important cellular organelles that govern the storage and turnover of
lipids. Little is known about how the size of LDs is controlled, although LDs of diverse sizes …

Mass spectrometry-based shotgun lipidomics has enabled the quantitative and
comprehensive assessment of cellular lipid compositions. The yeast Saccharomyces …

Lipid droplets (LDs) are conserved organelles for intracellular neutral lipid storage. Recent
studies suggest that LDs function as direct lipid sources for autophagy, a central catabolic …

The yeast Saccharomyces cerevisiae, with its full complement of organelles, synthesizes
membrane phospholipids by pathways that are generally common to those found in higher …