Protein aggregation is the hallmark of neurodegeneration, but the molecular mechanisms
underlying late-onset Alzheimer's disease (AD) are unclear. Here we integrated …

Thyroid cancer (TC) is one of the most frequent endocrine malignancies that is more
common among females. Tumor recurrence is one of the most important clinical …

Simple Summary RAD51 is an essential gene for cell survival. Its function is central to DNA
repair and it protects cells from life-threatening damage to the genome. Interestingly, RAD51 …

Abstract Background Long non-coding RNAs (lncRNAs) are crucial in the invasion,
angiogenesis, progression, and metastasis of hepatocellular carcinoma (HCC). The lncRNA …

Neutrophils are the most abundant human white blood cell and constitute a first line of
defense in the innate immune response. Neutrophils are short-lived cells and thus the …

The tumor microenvironment and its contribution to tumorigenesis has been a focal highlight
in recent years. A two-way communication between the tumor and the surrounding …

The DNA of all organisms is constantly damaged by physiological processes and
environmental conditions. Upon persistent damage, plant growth and cell proliferation are …

Background Glioblastoma multiforme (GBM) is the most aggressive form of brain cancer,
and chemoresistance poses a significant challenge to the survival and prognosis of GBM …

E2Fs are a family of pivotal transcription factors. Accumulative evidence indicates that
aberrant expression or activation of E2Fs is a common phenomenon in malignances, and …

Abstract E2F7 and E2F8 act as tumor suppressors via transcriptional repression of genes
involved in S‐phase entry and progression. Previously, we demonstrated that these atypical …