Prodrugs are molecules with little or no pharmacological activity that are converted to the
active parent drug in vivo by enzymatic or chemical reactions or by a combination of the two …

Prodrugs are bioreversible derivatives of drug molecules that undergo an enzymatic and/or
chemical transformation in vivo to release the active parent drug, which can then exert the …

Phosphine oxides and related phosphorus-containing functional groups such as
phosphonates and phosphinates are established structural motifs that are still …

Contemporary pharmaceutical pipelines are often highly populated with poorly water-
soluble drug candidates necessitating novel formulation technologies to provide dosage …

Since the 1960s the membrane‐bound enzyme alkaline phosphatase (ALP) has been
utilized in drug delivery. As it cleaves phosphate substructures from drugs, auxiliary agents …

Drug design in recent years has attempted to explore new chemical spaces resulting in
more complex, larger molecular weight molecules, often with limited water solubility. To …

Human immunodeficiency virus-1 (HIV-1) infection currently requires lifelong therapy with
drugs that are used in combination to control viremia. The indole-3-glyoxamide 6 was …

Nanocarriers (NCs) have emerged as powerful tools to improve drug solubility, to promote
drug transport across membranes, to protect their payload from premature degradation, and …

Acetals and ketals and their nitrogen and sulfur homologues are often considered to be
unconventional and potentially problematic scaffolding elements or pharmacophores for the …

New chemotherapeutic agents are urgently required to combat the global spread of
multidrug-resistant tuberculosis (MDR-TB). The mycobacterial enoyl reductase InhA is one …