In vitro and in silico modeling of endovascular stroke treatments for acute ischemic stroke

G Luraghi, RME Cahalane, E van de Ven… - Journal of …, 2021 - Elsevier
Acute ischemic stroke occurs when a thrombus obstructs a cerebral artery, leading to sub-
optimal blood perfusion to brain tissue. A recently developed, preventive treatment is the …

A Review of the Advancements in the in-vitro Modelling of Acute Ischemic Stroke and Its Treatment

S Johnson, A Dwivedi, M Mirza, R McCarthy… - Frontiers in Medical …, 2022 - frontiersin.org
In-vitro neurovascular models of large vessel occlusions (LVOs) causing acute ischemic
stroke (AIS) are used extensively for pre-clinical testing of new treatment devices. They …

Blood clot fracture properties are dependent on red blood cell and fibrin content

B Fereidoonnezhad, A Dwivedi, S Johnson… - Acta Biomaterialia, 2021 - Elsevier
Thrombus fragmentation during endovascular stroke treatment, such as mechanical
thrombectomy, leads to downstream emboli, resulting in poor clinical outcomes. Clinical …

Frontline thrombectomy strategy and outcome in acute basilar artery occlusion

M Abdelrady, J Ognard, F Cagnazzo, I Derraz… - Journal of …, 2023 - jnis.bmj.com
Background Novel thrombectomy strategies emanate expeditiously day-by-day counting on
access system, clot retriever device, proximity to and integration with the thrombus, and …

Electroacupuncture pretreatment alleviates rats cerebral ischemia-reperfusion injury by inhibiting ferroptosis

T Ye, N Zhang, A Zhang, X Sun, B Pang, X Wu - Heliyon, 2024 - cell.com
Objective To explore the preventive effect of electroacupuncture pretreatment on stroke in
rats by inhibiting ferroptosis and oxidative stress. Methods Rats were randomly assigned to …

Preclinical testing platforms for mechanical thrombectomy in stroke: a review on phantoms, in-vivo animal, and cadaveric models

Y Liu, M Abbasi, JLA Larco, R Kadirvel… - Journal of …, 2021 - jnis.bmj.com
Preclinical testing platforms have been instrumental in the research and development of
thrombectomy devices. However, there is no single model which fully captures the …

Intracranial artery calcifications profile as a predictor of recanalization failure in endovascular stroke treatment

M Rodrigo-Gisbert, M Requena, M Rubiera, J Khalife… - Stroke, 2023 - ahajournals.org
Background: Acute ischemic stroke with large or medium-vessel occlusion associated with
intracranial artery calcification (IAC) is an infrequent phenomenon presumably associated …

Water content for clot composition prediction in acute ischemic stroke

K Sakuta, T Imahori, A Molaie, M Ghovvati, N Rao… - Plos one, 2024 - journals.plos.org
Background Mechanical thrombectomy (MT) has become the gold standard care for treating
acute ischemic stroke (AIS) due to large vessel occlusion. Emerging evidence suggests that …

Aspects of ischemic stroke biomechanics derived using ex-vivo and in-vitro methods relating to mechanical thrombectomy

R McCarthy, M Mirza, S Johnson, A Dwivedi… - Journal of …, 2022 - Elsevier
Establishing the underlying biomechanics of acute ischemic stroke (AIS) and its treatment is
fundamental to develo** more effective clinical treatments for one of society's most …

Preclinical modeling of mechanical thrombectomy

V Anagnostakou, M Epshtein, AL Kühn, RM King… - Journal of …, 2022 - Elsevier
Mechanical thrombectomy to treat large vessel occlusions (LVO) causing a stroke is one of
the most effective treatments in medicine, with a number needed to treat to improve clinical …