Genetic susceptibility to triple-negative breast cancer
KN Stevens, CM Vachon, FJ Couch - Cancer research, 2013 - AACR
Triple-negative breast cancers (TNBC), defined by the absence of estrogen receptor,
progesterone receptor, and HER-2 expression, account for 12% to 24% of all breast …
progesterone receptor, and HER-2 expression, account for 12% to 24% of all breast …
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines
Recent work points to a lack of diversity in genomics studies from genome-wide association
studies to somatic (tumor) genome analyses. Yet, population-specific genetic variation has …
studies to somatic (tumor) genome analyses. Yet, population-specific genetic variation has …
Leveraging functional-annotation data in trans-ethnic fine-map** studies
Localization of causal variants underlying known risk loci is one of the main research
challenges following genome-wide association studies. Risk loci are typically dissected …
challenges following genome-wide association studies. Risk loci are typically dissected …
Genome-wide association analyses of breast cancer in women of African ancestry identify new susceptibility loci and improve risk prediction
We performed genome-wide association studies of breast cancer including 18,034 cases
and 22,104 controls of African ancestry. Genetic variants at 12 loci were associated with …
and 22,104 controls of African ancestry. Genetic variants at 12 loci were associated with …
Loss-of-function variants in ATM confer risk of gastric cancer
H Helgason, T Rafnar, HS Olafsdottir, JG Jonasson… - Nature …, 2015 - nature.com
Gastric cancer is a serious health problem worldwide, with particularly high prevalence in
eastern Asia. Genome-wide association studies (GWAS) in Asian populations have …
eastern Asia. Genome-wide association studies (GWAS) in Asian populations have …
Breast cancer risk variants at 6q25 display different phenotype associations and regulate ESR1, RMND1 and CCDC170
We analyzed 3,872 common genetic variants across the ESR1 locus (encoding estrogen
receptor α) in 118,816 subjects from three international consortia. We found evidence for at …
receptor α) in 118,816 subjects from three international consortia. We found evidence for at …
Variants associating with uterine leiomyoma highlight genetic background shared by various cancers and hormone-related traits
T Rafnar, B Gunnarsson, OA Stefansson… - Nature …, 2018 - nature.com
Uterine leiomyomas are common benign tumors of the myometrium. We performed a meta-
analysis of two genome-wide association studies of leiomyoma in European women (16,595 …
analysis of two genome-wide association studies of leiomyoma in European women (16,595 …
Genome-wide association study of breast cancer in Latinas identifies novel protective variants on 6q25
L Fejerman, N Ahmadiyeh, D Hu, S Huntsman… - Nature …, 2014 - nature.com
The genetic contributions to breast cancer development among Latinas are not well
understood. Here we carry out a genome-wide association study of breast cancer in Latinas …
understood. Here we carry out a genome-wide association study of breast cancer in Latinas …
Genome-wide association study identifies multiple loci associated with both mammographic density and breast cancer risk
Mammographic density reflects the amount of stromal and epithelial tissues in relation to
adipose tissue in the breast and is a strong risk factor for breast cancer. Here we report the …
adipose tissue in the breast and is a strong risk factor for breast cancer. Here we report the …
Unravelling modifiers of breast and ovarian cancer risk for BRCA1 and BRCA2 mutation carriers: update on genetic modifiers
Barnes DR, Antoniou AC (Centre for Cancer Genetic Epidemiology, University of
Cambridge, Cambridge, UK). Unravelling modifiers of breast and ovarian cancer risk for …
Cambridge, Cambridge, UK). Unravelling modifiers of breast and ovarian cancer risk for …