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CBASS to cGAS-STING: the origins and mechanisms of nucleotide second messenger immune signaling
Host defense against viral pathogens is an essential function for all living organisms. In cell-
intrinsic innate immunity, dedicated sensor proteins recognize molecular signatures of …
intrinsic innate immunity, dedicated sensor proteins recognize molecular signatures of …
RNA-targeting CRISPR–Cas systems
CRISPR–Cas is a widespread adaptive immune system in bacteria and archaea that
protects against viral infection by targeting specific invading nucleic acid sequences …
protects against viral infection by targeting specific invading nucleic acid sequences …
Bacterial defense systems exhibit synergistic anti-phage activity
Bacterial defense against phage predation involves diverse defense systems acting
individually and concurrently, yet their interactions remain poorly understood. We …
individually and concurrently, yet their interactions remain poorly understood. We …
DNA-targeting short Argonautes complex with effector proteins for collateral nuclease activity and bacterial population immunity
Two prokaryotic defence systems, prokaryotic Argonautes (pAgos) and CRISPR–Cas, detect
and cleave invader nucleic acids using complementary guides and the nuclease activities of …
and cleave invader nucleic acids using complementary guides and the nuclease activities of …
The evolutionary success of regulated cell death in bacterial immunity
Highlights•Many antiphage systems trigger regulated death of the infected cell.•Regulated
cell death protects the nearby population from the spread of infection.•Over 70% of …
cell death protects the nearby population from the spread of infection.•Over 70% of …
A long look at short prokaryotic Argonautes
Argonaute proteins (Agos) use small 15–30 nucleotide-long guides to bind and/or cleave
complementary target nucleic acids. Eukaryotic Agos mediate RNA-guided RNA silencing …
complementary target nucleic acids. Eukaryotic Agos mediate RNA-guided RNA silencing …
Type III CRISPR-Cas: beyond the Cas10 effector complex
Abstract Type III CRISPR-Cas loci encode some of the most abundant, yet complex, immune
systems of prokaryotes. They are composed of a Cas10 complex that uses an RNA guide to …
systems of prokaryotes. They are composed of a Cas10 complex that uses an RNA guide to …
RNA targeting and cleavage by the type III-Dv CRISPR effector complex
CRISPR-Cas are adaptive immune systems in bacteria and archaea that utilize CRISPR
RNA-guided surveillance complexes to target complementary RNA or DNA for destruction …
RNA-guided surveillance complexes to target complementary RNA or DNA for destruction …
An essential and highly selective protein import pathway encoded by nucleus-forming phage
Targeting proteins to specific subcellular destinations is essential in prokaryotes,
eukaryotes, and the viruses that infect them. Chimalliviridae phages encapsulate their …
eukaryotes, and the viruses that infect them. Chimalliviridae phages encapsulate their …
Nucleotide immune signaling in CBASS, Pycsar, Thoeris, and CRISPR antiphage defense
Bacteria encode an arsenal of diverse systems that defend against phage infection. A
common theme uniting many prevalent antiphage defense systems is the use of specialized …
common theme uniting many prevalent antiphage defense systems is the use of specialized …