Causes and consequences of snake venom variation

NR Casewell, TNW Jackson, AH Laustsen… - Trends in …, 2020 - cell.com
Snake venoms are mixtures of toxins that vary extensively between and within snake
species. This variability has serious consequences for the management of the world's 1.8 …

A current perspective on snake venom composition and constituent protein families

T Tasoulis, GK Isbister - Archives of toxicology, 2023 - Springer
Snake venoms are heterogeneous mixtures of proteins and peptides used for prey
subjugation. With modern proteomics there has been a rapid expansion in our knowledge of …

Phylogenetically diverse diets favor more complex venoms in North American pitvipers

ML Holding, JL Strickland… - Proceedings of the …, 2021 - National Acad Sciences
The role of natural selection in the evolution of trait complexity can be characterized by
testing hypothesized links between complex forms and their functions across species …

Micro and macroevolution of sea anemone venom phenotype

EG Smith, JM Surm, J Macrander, A Simhi… - Nature …, 2023 - nature.com
Venom is a complex trait with substantial inter-and intraspecific variability resulting from
strong selective pressures acting on the expression of many toxic proteins. However …

Whole genome duplication and gene evolution in the hyperdiverse venomous gastropods

S Farhat, MV Modica, N Puillandre - Molecular Biology and …, 2023 - academic.oup.com
The diversity of venomous organisms and the toxins they produce have been increasingly
investigated, but taxonomic bias remains important. Neogastropods, a group of marine …

The rise of genomics in snake venom research: recent advances and future perspectives

W Rao, K Kalogeropoulos, ME Allentoft… - …, 2022 - academic.oup.com
Snake venoms represent a danger to human health, but also a gold mine of bioactive
proteins that can be harnessed for drug discovery purposes. The evolution of snakes and …

Comprehensive isoform-level analysis reveals the contribution of alternative isoforms to venom evolution and repertoire diversity

X Ye, C He, Y Yang, YH Sun, S **ong… - Genome …, 2023 - genome.cshlp.org
Animal venom systems have emerged as valuable models for investigating how novel
polygenic phenotypes may arise from gene evolution by varying molecular mechanisms …

The Tiger Rattlesnake genome reveals a complex genotype underlying a simple venom phenotype

MJ Margres, RM Rautsaw… - Proceedings of the …, 2021 - National Acad Sciences
Variation in gene regulation is ubiquitous, yet identifying the mechanisms producing such
variation, especially for complex traits, is challenging. Snake venoms provide a model …

Tracking the recruitment and evolution of snake toxins using the evolutionary context provided by the Bothrops jararaca genome

DD Almeida, VL Viala, PG Nachtigall… - Proceedings of the …, 2021 - National Acad Sciences
Venom is a key adaptive innovation in snakes, and how nonvenom genes were co-opted to
become part of the toxin arsenal is a significant evolutionary question. While this process …

An ancient, conserved gene regulatory network led to the rise of oral venom systems

A Barua, AS Mikheyev - Proceedings of the National …, 2021 - National Acad Sciences
Oral venom systems evolved multiple times in numerous vertebrates, enabling the
exploitation of unique predatory niches. Yet how and when they evolved remains poorly …