Regulation of gene expression in trypanosomatids: living with polycistronic transcription
C Clayton - Open biology, 2019 - royalsocietypublishing.org
In trypanosomes, RNA polymerase II transcription is polycistronic and individual mRNAs are
excised by trans-splicing and polyadenylation. The lack of individual gene transcription …
excised by trans-splicing and polyadenylation. The lack of individual gene transcription …
Epigenetic regulation of genomic stability by vitamin C
JP Brabson, T Leesang, S Mohammad… - Frontiers in genetics, 2021 - frontiersin.org
DNA methylation plays an important role in the maintenance of genomic stability. Ten-
eleven translocation proteins (TETs) are a family of iron (Fe2+) and α-KG-dependent …
eleven translocation proteins (TETs) are a family of iron (Fe2+) and α-KG-dependent …
Long-range single-molecule map** of chromatin accessibility in eukaryotes
Map** open chromatin regions has emerged as a widely used tool for identifying active
regulatory elements in eukaryotes. However, existing approaches, limited by reliance on …
regulatory elements in eukaryotes. However, existing approaches, limited by reliance on …
Strain-specific genome evolution in Trypanosoma cruzi, the agent of Chagas disease
The protozoan Trypanosoma cruzi almost invariably establishes life-long infections in
humans and other mammals, despite the development of potent host immune responses …
humans and other mammals, despite the development of potent host immune responses …
Enzymatic synthesis of base-functionalized nucleic acids for sensing, cross-linking, and modulation of protein–DNA binding and transcription
M Hocek - Accounts of Chemical Research, 2019 - ACS Publications
Conspectus Protein–DNA interactions are important in replication, transcription, repair, as
well as epigenetic modifications of DNA, which involve methylation and demethylation of …
well as epigenetic modifications of DNA, which involve methylation and demethylation of …
Map** and elucidating the function of modified bases in DNA
Chemically modified bases exist naturally in genomic DNA. Research into these bases has
been invigorated by the discovery of several modified bases in the mammalian genome, in …
been invigorated by the discovery of several modified bases in the mammalian genome, in …
Non‐canonical bases in the genome: the regulatory information layer in DNA
T Carell, MQ Kurz, M Müller, M Rossa… - Angewandte Chemie …, 2018 - Wiley Online Library
Multicellular organisms developed the concept of specialized cells that perform specific
functions. Examples are neurons and fibroblast to name just two out of more than 200 …
functions. Examples are neurons and fibroblast to name just two out of more than 200 …
Detection, structure and function of modified DNA bases
While some DNA base modifications such as 5-methylcytosine have been known and
studied for decades, recent discoveries of a number of other modified bases have stimulated …
studied for decades, recent discoveries of a number of other modified bases have stimulated …
Sequencing abasic sites in DNA at single-nucleotide resolution
In DNA, the loss of a nucleobase by hydrolysis generates an abasic site. Formed as a result
of DNA damage, as well as a key intermediate during the base excision repair pathway …
of DNA damage, as well as a key intermediate during the base excision repair pathway …
Leishmania-Host Interactions—An Epigenetic Paradigm
Leishmaniasis is one of the major neglected tropical diseases, for which no vaccines exist.
Chemotherapy is hampered by limited efficacy coupled with development of resistance and …
Chemotherapy is hampered by limited efficacy coupled with development of resistance and …