[HTML][HTML] Multidisciplinary strategies to enhance therapeutic effects of flavonoids from Epimedii Folium: Integration of herbal medicine, enzyme engineering, and …

Y Lu, Q Luo, X Jia, JP Tam, H Yang, Y Shen… - Journal of Pharmaceutical …, 2023 - Elsevier
Flavonoids such as baohuoside I and icaritin are the major active compounds in Epimedii
Folium (EF) and possess excellent therapeutic effects on various diseases. Encouragingly …

Targeting the tumour vasculature: from vessel destruction to promotion

S Guelfi, K Hodivala-Dilke, G Bergers - Nature Reviews Cancer, 2024 - nature.com
As angiogenesis was recognized as a core hallmark of cancer growth and survival, several
strategies have been implemented to target the tumour vasculature. Yet to date, attempts …

Cruciferous vegetables and their bioactive metabolites: from prevention to novel therapies of colorectal cancer

D Ağagündüz, TÖ Şahin, B Yılmaz… - Evidence‐Based …, 2022 - Wiley Online Library
The Brassicaceae family, known as cruciferous vegetables, includes many economically
important species, mainly edible oil plants, vegetable species, spice plants, and feed plants …

A review on anti-cancer properties of Quercetin in breast cancer

M Ezzati, B Yousefi, K Velaei, A Safa - Life sciences, 2020 - Elsevier
Breast cancer is one of the well-known malignant tumors among women. In spite of attempts
to classifying breast cancer according to its histological and molecular properties, it is almost …

Flavonoids from Whole-Grain Oat Alleviated High-Fat Diet-Induced Hyperlipidemia via Regulating Bile Acid Metabolism and Gut Microbiota in Mice

R Duan, X Guan, K Huang, Y Zhang, S Li… - Journal of Agricultural …, 2021 - ACS Publications
A high-fat diet (HFD) causes hyperlipidemia, which worsens disturbances in bile acid (BA)
metabolism and gut microbiota. This study aimed to investigate the regulation of flavonoids …

Neuroprotective effects of quercetin in Alzheimer's disease

H Khan, H Ullah, M Aschner, WS Cheang, EK Akkol - Biomolecules, 2019 - mdpi.com
Quercetin is a flavonoid with notable pharmacological effects and promising therapeutic
potential. It is widely distributed among plants and found commonly in daily diets …

Opportunities and challenges in enhancing the bioavailability and bioactivity of dietary flavonoids: A novel delivery system perspective

D Yuan, Y Guo, F Pu, C Yang, X **ao, H Du, J He, S Lu - Food Chemistry, 2024 - Elsevier
Flavonoids have multiple favorable bioactivities including antioxidant, anti-inflammatory, and
antitumor. Currently, flavonoid-containing dietary supplements are widely tested in clinical …

The therapeutic potential of anthocyanins: current approaches based on their molecular mechanism of action

B Salehi, J Sharifi-Rad, F Cappellini, Ž Reiner… - Frontiers in …, 2020 - frontiersin.org
Anthocyanins are natural phenolic pigments with biological activity. They are well-known to
have potent antioxidant and antiinflammatory activity, which explains the various biological …

[HTML][HTML] The anticancer mechanism of action of selected polyphenols in triple-negative breast cancer (TNBC)

R Farghadani, R Naidu - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Breast cancer is a leadingcause of cancer-related deaths in women globally, with triple-
negative breast cancer (TNBC) being an aggressive subtype that lacks targeted therapies …

Medicinal chemistry strategies to discover P-glycoprotein inhibitors: An update

J Dong, Z Qin, WD Zhang, G Cheng, AG Yehuda… - Drug Resistance …, 2020 - Elsevier
The presence of multidrug resistance (MDR) in malignant tumors is one of the primary
causes of treatment failure in cancer chemotherapy. The overexpression of the ATP binding …