Decoding the brain: From neural representations to mechanistic models

MW Mathis, AP Rotondo, EF Chang, AS Tolias… - Cell, 2024 - cell.com
A central principle in neuroscience is that neurons within the brain act in concert to produce
perception, cognition, and adaptive behavior. Neurons are organized into specialized brain …

Functional connectomics spanning multiple areas of mouse visual cortex

MICrONS Consortium, JA Bae, M Baptiste, CA Bishop… - BioRxiv, 2021 - biorxiv.org
To understand the brain we must relate neurons' functional responses to the circuit
architecture that shapes them. Here, we present a large functional connectomics dataset …

Functional specificity of recurrent inhibition in visual cortex

P Znamenskiy, MH Kim, DR Muir, MF Iacaruso… - Neuron, 2024 - cell.com
In the neocortex, neural activity is shaped by the interaction of excitatory and inhibitory
neurons, defined by the organization of their synaptic connections. Although connections …

The logic of recurrent circuits in the primary visual cortex

IA Oldenburg, WD Hendricks, G Handy… - Nature …, 2024 - nature.com
Recurrent cortical activity sculpts visual perception by refining, amplifying or suppressing
visual input. However, the rules that govern the influence of recurrent activity remain …

Stimulus type shapes the topology of cellular functional networks in mouse visual cortex

D Tang, J Zylberberg, X Jia, H Choi - Nature Communications, 2024 - nature.com
On the timescale of sensory processing, neuronal networks have relatively fixed anatomical
connectivity, while functional interactions between neurons can vary depending on the …

Towards a foundation model of the mouse visual cortex

EY Wang, PG Fahey, K Ponder, Z Ding, A Chang… - bioRxiv, 2023 - biorxiv.org
Understanding the brain's perception algorithm is a highly intricate problem, as the inherent
complexity of sensory inputs and the brain's nonlinear processing make characterizing …

Deep learning-driven characterization of single cell tuning in primate visual area V4 unveils topological organization

KF Willeke, K Restivo, K Franke, AF Nix, SA Cadena… - bioRxiv, 2023 - biorxiv.org
Deciphering the brain's structure-function relationship is key to understanding the neuronal
mechanisms underlying perception and cognition. The cortical column, a vertical …

The dynamic sensorium competition for predicting large-scale mouse visual cortex activity from videos

P Turishcheva, PG Fahey, M Vystrčilová, L Hansel… - Ar**v, 2024 - pmc.ncbi.nlm.nih.gov
Understanding how biological visual systems process information is challenging due to the
complex nonlinear relationship between neuronal responses and high-dimensional visual …

Specific inhibition and disinhibition in the higher-order structure of a cortical connectome

MW Reimann, D Egas Santander, A Ecker… - Cerebral …, 2024 - academic.oup.com
Neurons are thought to act as parts of assemblies with strong internal excitatory connectivity.
Conversely, inhibition is often reduced to blanket inhibition with no targeting specificity. We …

Deciphering the genetic code of neuronal type connectivity through bilinear modeling

M Qiao - Elife, 2024 - elifesciences.org
Understanding how different neuronal types connect and communicate is critical to
interpreting brain function and behavior. However, it has remained a formidable challenge to …