Designed to degrade: tailoring polyesters for circularity

CV Aarsen, A Liguori, R Mattsson… - Chemical …, 2024 - ACS Publications
A powerful toolbox is needed to turn the linear plastic economy into circular. Development of
materials designed for mechanical recycling, chemical recycling, and/or biodegradation in …

Reactive oxygen species-upregulating nanomedicines towards enhanced cancer therapy

Y Ding, Q Pan, W Gao, Y Pu, K Luo, B He - Biomaterials Science, 2023 - pubs.rsc.org
Reactive oxygen species (ROS) play a crucial role in physiological and pathological
processes, emerging as a therapeutic target in cancer. Owing to the high concentration of …

Triggerable prodrug nanocoating enables on-demand activation of microbial and small-molecular therapeutics for combination treatment

X Kuang, Y Liu, H Luo, Q Li, F Wu… - Journal of the American …, 2023 - ACS Publications
The synergy of living microbial and small-molecular therapeutics has been widely explored
for treating a variety of diseases, while current combination strategies often suffer from low …

Sequentially responsive biomimetic nanoparticles with optimal size in combination with checkpoint blockade for cascade synergetic treatment of breast cancer and …

W Yu, X He, Z Yang, X Yang, W **ao, R Liu, R **e… - Biomaterials, 2019 - Elsevier
Recently, photodynamic therapy (PDT) emerges as a promising way to initiate immune
response and being used in combination with chemotherapy. However, the antitumor effect …

Oxidative stress amplifiers as immunogenic cell death nanoinducers disrupting mitochondrial redox homeostasis for cancer immunotherapy

J Wan, X Zhang, Z Li, F Mo, D Tang… - Advanced …, 2023 - Wiley Online Library
Reactive oxygen species (ROS)‐induced oxidative stress in the endoplasmic reticulum (ER)
is generally believed to be an important prerequisite for immunogenic cell death (ICD) which …

A reactive oxygen species-replenishing coordination polymer nanomedicine disrupts redox homeostasis and induces concurrent apoptosis-ferroptosis for …

Z Zhang, Y Pan, JE Cun, J Li, Z Guo, Q Pan, W Gao… - Acta Biomaterialia, 2022 - Elsevier
Reactive oxygen species (ROS) are important signal molecules and imbalanced ROS level
could lead to cell death. Elevated ROS levels in tumor tissues offer an opportunity to design …

Structural determinants of stimuli-responsiveness in amphiphilic macromolecular nano-assemblies

H Liu, HH Lu, Y Alp, R Wu, S Thayumanavan - Progress in Polymer …, 2024 - Elsevier
Stimuli-responsive nano-assemblies from amphiphilic macromolecules could undergo
controlled structural transformations and generate diverse macroscopic phenomenon under …

Reactive oxygen species responsive polymers for drug delivery systems

F Gao, Z **ong - Frontiers in Chemistry, 2021 - frontiersin.org
Reactive oxygen species (ROS) play an essential role in regulating various physiological
functions of living organisms; however, as the concentration of ROS increases in the area of …

Redox-sensitive polymeric micelles with aggregation-induced emission for bioimaging and delivery of anticancer drugs

C Sun, J Lu, J Wang, P Hao, C Li, L Qi, L Yang… - Journal of …, 2021 - Springer
Background Nano-drug delivery systems show considerable promise for effective cancer
therapy. Polymeric micelles have attracted extensive attention as practical nanocarriers for …

Highly stable, coordinated polymeric nanoparticles loading copper (II) diethyldithiocarbamate for combinational chemo/chemodynamic therapy of cancer

X Peng, Q Pan, B Zhang, S Wan, S Li, K Luo… - …, 2019 - ACS Publications
Disulfiram (DSF) has excellent in vitro anticancer activity in the presence of Cu (II). The
anticancer mechanism studies have demonstrated that copper (II) diethyldithiocarbamate …