Photodynamic therapy: a brief history

D Kessel - Journal of clinical medicine, 2019 - mdpi.com
Photodynamic therapy (PDT) involves the selective sensitization of tissues to light. A major
advance in the field occurred when Thomas Dougherty at the Roswell Park Cancer Institute …

Photodynamic therapy and the biophysics of the tumor microenvironment

AJ Sorrin, M Kemal Ruhi, NA Ferlic… - Photochemistry and …, 2020 - Wiley Online Library
Targeting the tumor microenvironment (TME) provides opportunities to modulate tumor
physiology, enhance the delivery of therapeutic agents, impact immune response and …

Role of ultrasound and photoacoustic imaging in photodynamic therapy for cancer

SC Hester, M Kuriakose, CD Nguyen… - Photochemistry and …, 2020 - Wiley Online Library
Photodynamic therapy (PDT) is a phototoxic treatment with high spatial and temporal control
and has shown tremendous promise in the management of cancer due to its high efficacy …

Platelet membrane camouflaged AIEgen‐mediated photodynamic therapy improves the effectiveness of anti‐PD‐L1 immunotherapy in large‐burden tumors

J Dai, M Wu, Y Xu, H Yao, X Lou… - Bioengineering & …, 2023 - Wiley Online Library
Although immunotherapy has achieved recent clinical success in antitumor therapy, it is less
effective for solid tumors with large burdens. To overcome this challenge, herein, we report a …

Vitamin D receptor activation and photodynamic priming enables durable low-dose chemotherapy

S Anbil, M Pigula, HC Huang, S Mallidi… - Molecular cancer …, 2020 - AACR
Patients with cancer often confront the decision of whether to continue high-dose
chemotherapy at the expense of cumulative toxicities. Reducing the dose of chemotherapy …

Breaking the selectivity-uptake trade-off of photoimmunoconjugates with nanoliposomal irinotecan for synergistic multi-tier cancer targeting

BJ Liang, M Pigula, Y Baglo, D Najafali… - Journal of …, 2020 - Springer
Background Photoimmunotherapy involves targeted delivery of photosensitizers via an
antibody conjugate (ie, photoimmunoconjugate, PIC) followed by light activation for selective …

Predictors and limitations of the penetration depth of photodynamic effects in the rodent brain

CT Inglut, B Gaitan, D Najafali, IA Lopez… - Photochemistry and …, 2020 - Wiley Online Library
Fluorescence‐guided surgery (FGS) is routinely utilized in clinical centers around the world,
whereas the combination of FGS and photodynamic therapy (PDT) has yet to reach clinical …

Single-Cell RNA sequencing reveals immuno-oncology characteristics of tumor-infiltrating t lymphocytes in photodynamic therapy-treated colorectal cancer mouse …

EJ Lee, JG Choi, JH Han, YW Kim, J Lim… - International Journal of …, 2023 - mdpi.com
Photodynamic therapy (PDT) has shown promise in reducing metastatic colorectal cancer
(CRC); however, the underlying mechanisms remain unclear. Modulating tumor-infiltrating …

Combined fluorescence and optoacoustic imaging for monitoring treatments against ct26 tumors with photoactivatable liposomes

I Turchin, S Bano, M Kirillin, A Orlova, V Perekatova… - Cancers, 2021 - mdpi.com
Simple Summary A new approach of combined optoacoustic (OA) and fluorescence (FL)
imaging for in vivo real-time tracing photosensitizer (PS) kinetics and functional vascular …

In vivo C6 glioma models: an update and a guide toward a more effective preclinical evaluation of potential anti-glioblastoma drugs

S Pournajaf, N Afsordeh… - Reviews in the …, 2024 - degruyter.com
Glioblastoma multiform (GBM) is the most common primary brain tumor with a poor
prognosis and few therapeutic choices. In vivo, tumor models are useful for enhancing …