Cognitive deficits are a core feature of schizophrenia, account for much of the impaired
functioning associated with the disorder and are not responsive to existing treatments. In this …

Cortical gain regulation allows neurons to respond adaptively to changing inputs. Neural
gain is modulated by internal and external influences, including attentional and arousal …

In the hippocampus GABAergic local circuit inhibitory interneurons represent only~ 10–15%
of the total neuronal population; however, their remarkable anatomical and physiological …

Although a wealth of data have elucidated the structure and physiology of neuronal circuits,
we still only have a very limited understanding of how behavioral learning is implemented at …

Different subtypes of GABAergic neurons in sensory cortex exhibit diverse morphology,
histochemical markers, and patterns of connectivity. These subtypes likely play distinct roles …

The prefrontal cortex (PFC) plays a key role in controlling goal-directed behavior. Although a
variety of task-related signals have been observed in the PFC, whether they are differentially …

Cortical sensory maps are remodeled during early life to adapt to the surrounding
environment. Both sensory and contextual signals are important for induction of this …

Neocortex, the neuronal structure at the base of the remarkable cognitive skills of mammals,
is a layered sheet of neuronal tissue composed of juxtaposed and interconnected columns …

B cells are important in the development of autoimmune disorders by mechanisms involving
disregulated polyclonal B-cell activation, production of pathogenic antibodies, and co …

Recent evidence supports the hypothesis of a functional dichotomy of perisomatic inhibition
in the cerebral cortex: the parvalbumin-and cholecystokinin-containing basket cells that are …