Whole genome identification of Mycobacterium tuberculosisvaccine candidates by comprehensive data mining and bioinformatic analyses
A Zvi, N Ariel, J Fulkerson, JC Sadoff… - BMC medical …, 2008 - Springer
Background Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), infects~ 8
million annually culminating in~ 2 million deaths. Moreover, about one third of the …
million annually culminating in~ 2 million deaths. Moreover, about one third of the …
Tuberculosis: vaccines in the pipeline
LH Ly, DN McMurray - Expert Review of Vaccines, 2008 - Taylor & Francis
TB is presenting new challenges as a global health problem, especially with new threats of
HIV coinfection and multidrug-resistant and extensively drug-resistant strains of …
HIV coinfection and multidrug-resistant and extensively drug-resistant strains of …
Immunity to Intracellular Salmonella Depends on Surface-associated Antigens
S Barat, Y Willer, K Rizos, B Claudi, A Mazé… - 2012 - journals.plos.org
Invasive Salmonella infection is an important health problem that is worsening because of
rising antimicrobial resistance and changing Salmonella serovar spectrum. Novel vaccines …
rising antimicrobial resistance and changing Salmonella serovar spectrum. Novel vaccines …
Deciphering the proteome of the in vivo diagnostic reagent “purified protein derivative” from Mycobacterium tuberculosis
Purified protein derivative (PPD) has served as a safe and effective diagnostic reagent for 60
years and is the only broadly available material to diagnose latent tuberculosis infections …
years and is the only broadly available material to diagnose latent tuberculosis infections …
Adjuvants in tuberculosis vaccine development
Tuberculosis remains a major public health problem around the world. Because the
Mycobacterium bovis Bacilli–Calmette–Guerin (BCG) vaccine fails to protect adults from …
Mycobacterium bovis Bacilli–Calmette–Guerin (BCG) vaccine fails to protect adults from …
An Immunoinformatics-Based Study of Mycobacterium tuberculosis Region of Difference-2 Uncharacterized Protein (Rv1987) as a Potential Subunit Vaccine Candidate for …
Mycobacterium tuberculosis (Mtb) is the pathogen that causes tuberculosis and develops
resistance to many of the existing drugs. The sole licensed TB vaccine, BCG, is unable to …
resistance to many of the existing drugs. The sole licensed TB vaccine, BCG, is unable to …
O-mannosylation of the Mycobacterium tuberculosis Adhesin Apa Is Crucial for T Cell Antigenicity during Infection but Is Expendable for Protection
Glycosylation is the most abundant post-translational polypeptide chain modification in
nature. Although carbohydrate modification of protein antigens from many microbial …
nature. Although carbohydrate modification of protein antigens from many microbial …
A Proteome-Scale Identification of Novel Antigenic Proteins in Mycobacterium tuberculosis toward Diagnostic and Vaccine Development
Y Li, J Zeng, J Shi, M Wang, M Rao, C Xue… - Journal of proteome …, 2010 - ACS Publications
Tuberculosis (TB) remains to be a major infectious disease throughout the world. However,
the current vaccine for TB has variable protective efficacy, and there is no commercially …
the current vaccine for TB has variable protective efficacy, and there is no commercially …
Comparison of different immunization routes on the immune responses induced by Mycobacterium tuberculosis ESAT-6/CFP-10 recombinant protein
According to some difficulties against tuberculosis (TB) vaccination, development of new TB
vaccines has been noted in recent years. Selection of proper route for vaccination is one of …
vaccines has been noted in recent years. Selection of proper route for vaccination is one of …
Polypeptide vaccine and vaccination strategy against mycobacterium
(57) ABSTRACT A vaccine is provided wherein a polypeptide or combination of peptides
from M. tuberculosis is administered to a subject to elicit an immune response. The …
from M. tuberculosis is administered to a subject to elicit an immune response. The …