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Boron in cancer therapeutics: An overview
Boron has become a crucial weapon in anticancer research due to its significant intervention
in cell proliferation. Being an excellent bio-isosteric replacement of carbon, it has modulated …
in cell proliferation. Being an excellent bio-isosteric replacement of carbon, it has modulated …
Boronic acid-based arginase inhibitors in cancer immunotherapy
B Borek, T Gajda, A Golebiowski… - Bioorganic & Medicinal …, 2020 - Elsevier
Arginase is an enzyme that converts l-arginine to l-ornithine and urea in the urea cycle.
There are two isoforms of arginase in mammals: ARG-1 and ARG-2. l-Arginine level …
There are two isoforms of arginase in mammals: ARG-1 and ARG-2. l-Arginine level …
Compositions and methods for inhibiting arginase activity
EB Sjogren, J Li, M Van Zandt… - US Patent 10,065,974, 2018 - Google Patents
103068830 A 4/2013 103402549 A 11/2013 105879030 A 8/2016 WO-1999/019295 A1
4/1999 WO-2007/005620 A2 1/2007 WO-2010/085797 A2 7/2010 WO-2011/133653 Al …
4/1999 WO-2007/005620 A2 1/2007 WO-2010/085797 A2 7/2010 WO-2011/133653 Al …
Compositions and methods for inhibiting arginase activity
MI Gross, SM Steggerda, W Li - US Patent 10,143,699, 2018 - Google Patents
2431080 Al 12/2004 103068830 A 4/2013 103402549 A 11/2013 105879030 A 8/2016 WO-
99/19295 AL 4/1999 WO-2007/005620 A2 1/2007 WO-2010/085797 A2 7/2010 WO …
99/19295 AL 4/1999 WO-2007/005620 A2 1/2007 WO-2010/085797 A2 7/2010 WO …
Compositions and methods for inhibiting arginase activity
EB Sjogren, J Li, L Chen, RJ Billedeau… - US Patent …, 2019 - Google Patents
CAS Registry No. 1374395-07-9. CA Index Name:“3-Pyrrolidinecarboxylic acid, 3-amino-4-
(3-boronopropyl)-14 (5, 7-dichloro-1, 2, 3, 4-tetrahydro-3-isoquinolinyl) carbonyll-,(3R, 4S) …
(3-boronopropyl)-14 (5, 7-dichloro-1, 2, 3, 4-tetrahydro-3-isoquinolinyl) carbonyll-,(3R, 4S) …
Method of preparing (3R, 4S)-3-acetamido-4-allyl-N-(tert-butyl) pyrrolidine-3-carboxamide
MC Van Zandt, JL Savoy - US Patent 10,494,339, 2019 - Google Patents
Human Type II Argmase”, Biochem, 40 (31): 9356-9362. Curtis, B. et al. 2013" Secondary
amines containing one aromatic nitro group: preparation, nitrosation, sustained nitric oxide …
amines containing one aromatic nitro group: preparation, nitrosation, sustained nitric oxide …
Compositions and methods for inhibiting arginase activity
MI Gross, SM Steggerda, W Li - US Patent 10,398,714, 2019 - Google Patents
US10398714B2 - Compositions and methods for inhibiting arginase activity - Google
Patents US10398714B2 - Compositions and methods for inhibiting arginase activity …
Patents US10398714B2 - Compositions and methods for inhibiting arginase activity …
Compositions and methods for inhibiting arginase activity
EB Sjogren, J Li, L Chen, RJ Billedeau… - US Patent …, 2021 - Google Patents
Steggerda, Susanne M., et al. 2017,“Inhibition of arginase by CB-1158 blocks myeloid cell-
mediated immune suppression in the tumor microenvironment,” Journal for ImmunoTherapy …
mediated immune suppression in the tumor microenvironment,” Journal for ImmunoTherapy …
Compositions and methods for inhibiting arginase activity
EB Sjogren, J Li, M Van Zandt… - US Patent 10,844,080, 2020 - Google Patents
The invention relates to a novel class of compounds that exhibit activity inhibitory activity
toward arginase, and pharmaceutical compositions comprising the compounds of the …
toward arginase, and pharmaceutical compositions comprising the compounds of the …
Method of preparing (3R, 4S)-3-acetamido-4-allyl-n-(tert-butyl) pyrrolidine-3-carboxamide
MC Van Zandt, JL Savoy - US Patent 10,906,872, 2021 - Google Patents
OTHER PUBLICATIONS CAS Registry Number: 1374395-07-9. CA Index Name:" 3-Pyr
rolidinecarboxylic acid, 3-amino-4-(3-boronopropyl)-14 (5, 7-dichloro 1, 2, 3, 4-tetrahydro-3 …
rolidinecarboxylic acid, 3-amino-4-(3-boronopropyl)-14 (5, 7-dichloro 1, 2, 3, 4-tetrahydro-3 …