With both catalytic and genetic functions, ribonucleic acid (RNA) is perhaps the most
pluripotent chemical species in molecular biology, and its functions are intimately linked to …

From Levinthal to pathways to funnels Page 1 © 1997 Nature Publishing Group http://www.nature.com/nsmb
perspective From Levinthal to pathways to funnels Ken A. Dill and Hue Sun Chan A new …

With both catalytic and genetic functions, ribonucleic acid (RNA) is perhaps the most
pluripotent chemical species in molecular biology, and its functions are intimately linked to …

The mechanism of protein folding (represented schematically below) is one of the most
fascinating problems in the field of chemical reactions. This review presents the progess …

Proteins have dynamic structures that undergo chain motions on time scales spanning from
picoseconds to seconds. Resolving the resultant conformational heterogeneity is essential …

Direct observation of the detailed conformational fluctuations of a single protein molecule en
route to its folded state has so far been realized only in silico. We have used single-molecule …

Experiment and theory are converging on the importance of nucleation mechanisms in
protein folding. These mechanisms do not use classic nuclei, which are well formed …

The quantitative description of model protein folding kinetics using a diffusive collective
reaction coordinate is examined. Direct folding kinetics, diffusional coefficients and free …

▪ Abstract Beginning with simplified lattice and continuum “minimalist” models and
progressing to detailed atomic models, simulation studies have augmented and directed …

Publisher Summary This chapter deals with the structure of the molten globules of various
globular proteins revealed by the recent experimental studies. Recent advances in …