RNA‐binding proteins in pain

PR Smith, ZT Campbell - Wiley Interdisciplinary Reviews: RNA, 2024 - Wiley Online Library
RNAs are meticulously controlled by proteins. Through direct and indirect associations,
every facet in the brief life of an mRNA is subject to regulation. R NA‐b inding p roteins …

A compendium of validated pain genes

E Wistrom, R Chase, PR Smith… - WIREs Mechanisms of …, 2022 - Wiley Online Library
The development of novel pain therapeutics hinges on the identification and rigorous
validation of potential targets. Model organisms provide a means to test the involvement of …

Reversal of RNA toxicity in myotonic dystrophy via a decoy RNA-binding protein with high affinity for expanded CUG repeats

L Arandel, M Matloka, AF Klein, F Rau… - Nature Biomedical …, 2022 - nature.com
Abstract Myotonic dystrophy type 1 (DM1) is an RNA-dominant disease whose pathogenesis
stems from the functional loss of muscleblind-like RNA-binding proteins (RBPs), which …

Global analyses of mRNA expression in human sensory neurons reveal eIF5A as a conserved target for inflammatory pain

R Chase, JB de la Peña, PR Smith… - The FASEB …, 2022 - Wiley Online Library
Nociceptors are a type of sensory neuron that are integral to most forms of pain. Targeted
disruption of nociceptor sensitization affords unique opportunities to prevent pain. An …

[HTML][HTML] RNA binding proteins (RBPs) on genetic stability and diseases

AT Aborode, OA Abass, S Nasiru, MU Eigbobo… - Global Medical …, 2024 - Elsevier
RNA-binding proteins (RBPs) are integral components of cellular machinery, playing crucial
roles in the regulation of gene expression and maintaining genetic stability. Their …

CRISPR Based Programmable RNA Editing in Primary Hippocampal Neurons

K Ravichandran, T Khargonkar, S Samaddar… - Current …, 2023 - Wiley Online Library
Investigating the RNA regulation landscape primarily relies on understanding how RNA‐
protein interactions are governed in various cell types, including neurons. Analysis of RNA …

[PDF][PDF] Viral Hijacking of Host RNA-Binding Proteins: Implications for Viral Replication and Pathogenesis

NNT Cyrielle, MK Chanelle, AS ANDIGEMA - 2024 - preprints.org
In the intricate dance between viruses and host cells, RNA-binding proteins (RBPs) serve as
crucial orchestrators of gene expression and cellular processes. We will delve into the …

CRISPR based programmable RNA editing in primary neurons

K Ravichandran, T Khargonkar, S Samaddar… - bioRxiv, 2023 - biorxiv.org
Investigating the RNA regulation landscape primarily relies on our understanding of how
RNA-protein interactions are governed in various cell types, including neurons. Analysis of …