Adjuvant and salvage radiotherapy after radical prostatectomy in prostate cancer patients

G Gandaglia, A Briganti, N Clarke, RJ Karnes… - European urology, 2017 - Elsevier
Abstract Context Prostate cancer (PCa) patients found to have adverse pathologic features
following radical prostatectomy (RP) are less likely to be cured with surgery alone. Objective …

Metformin as a radiation modifier; implications to normal tissue protection and tumor sensitization

K Mortezaee, D Shabeeb, AE Musa… - Current clinical …, 2019 - ingentaconnect.com
Background: Nowadays, ionizing radiation is used for several applications in medicine,
industry, agriculture, and nuclear power generation. Besides the beneficial roles of ionizing …

Dose-intensified versus conventional-dose salvage radiotherapy for biochemically recurrent prostate cancer after prostatectomy: the SAKK 09/10 randomized phase 3 …

P Ghadjar, S Hayoz, J Bernhard, DR Zwahlen… - European urology, 2021 - Elsevier
Background Salvage radiotherapy (SRT) is utilized for biochemical progression of prostate
cancer after radical prostatectomy (RP). Objective To report the outcomes of the SAKK 09/10 …

Improved metastasis-free and survival outcomes with early salvage radiotherapy in men with detectable prostate-specific antigen after prostatectomy for prostate …

BJ Stish, TM Pisansky, WS Harmsen… - Journal of Clinical …, 2016 - ascopubs.org
Purpose To describe outcomes of salvage radiotherapy (SRT) for men with detectable
prostate-specific antigen (PSA) after radical prostatectomy for prostate cancer and identify …

Focal therapy in primary localised prostate cancer: the European Association of Urology position in 2018

HG van der Poel, RCN van den Bergh, E Briers… - European urology, 2018 - Elsevier
Radical treatment of localised prostate cancer is recognised to be an unnecessary
intervention or overtreatment in many men. Consequently, there has been a rapid uptake in …

[HTML][HTML] Quality-of-life outcomes and toxicity profile among patients with localized prostate cancer after radical prostatectomy treated with stereotactic body radiation …

TM Ma, LK Ballas, H Wilhalme, A Sachdeva… - International Journal of …, 2023 - Elsevier
Purpose Postoperative radiation therapy (RT) is an underused standard-of-care intervention
for patients with prostate cancer and recurrence/adverse pathologic features after radical …

Patient experience captured by quality-of-life measurement in oncology clinical trials

A Haslam, D Herrera-Perez, J Gill… - JAMA network open, 2020 - jamanetwork.com
Importance Quality of life (QoL) is an important consideration in cancer medicine, especially
because drugs are becoming more costly and may only result in modest gains in overall …

Salvage therapy for prostate cancer after radical prostatectomy

NG Zaorsky, J Calais, S Fanti, D Tilki, T Dorff… - Nature Reviews …, 2021 - nature.com
More than 40% of men with intermediate-risk or high-risk prostate cancer will experience a
biochemical recurrence after radical prostatectomy. Clinical guidelines for the management …

Outcome after PSMA PET/CT–based salvage radiotherapy in patients with biochemical recurrence after radical prostatectomy: a 2-institution retrospective analysis

NS Schmidt-Hegemann, C Stief, TH Kim… - Journal of Nuclear …, 2019 - jnm.snmjournals.org
Prostate-specific membrane antigen (PSMA) PET/CT detects prostate cancer recurrence at
low levels of prostate-specific antigen (PSA). Radiotherapy with dose escalation to the …

The dose–response of salvage radiotherapy following radical prostatectomy: a systematic review and meta-analysis

CR King - Radiotherapy and Oncology, 2016 - Elsevier
Purpose/objectives To date neither the optimal radiotherapy dose nor the existence of a
dose–response has been established for salvage RT (SRT). Materials/methods A systematic …