Structural biology of SARS-CoV-2: open the door for novel therapies

W Yan, Y Zheng, X Zeng, B He, W Cheng - Signal Transduction and …, 2022 - nature.com
Abstract Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is the causative
agent of the pandemic disease COVID-19, which is so far without efficacious treatment. The …

SARS-CoV-2 accessory proteins in viral pathogenesis: knowns and unknowns

N Redondo, S Zaldívar-López, JJ Garrido… - Frontiers in …, 2021 - frontiersin.org
There are still many unanswered questions concerning viral SARS-CoV-2 pathogenesis in
COVID-19. Accessory proteins in SARS-CoV-2 consist of eleven viral proteins whose roles …

[HTML][HTML] ORF3a of the COVID-19 virus SARS-CoV-2 blocks HOPS complex-mediated assembly of the SNARE complex required for autolysosome formation

G Miao, H Zhao, Y Li, M Ji, Y Chen, Y Shi, Y Bi… - Developmental cell, 2021 - cell.com
Autophagy acts as a cellular surveillance mechanism to combat invading pathogens.
Viruses have evolved various strategies to block autophagy and even subvert it for their …

SARS-CoV-2 virulence factor ORF3a blocks lysosome function by modulating TBC1D5-dependent Rab7 GTPase cycle

K Walia, A Sharma, S Paul, P Chouhan… - Nature …, 2024 - nature.com
Abstract SARS-CoV-2, the causative agent of COVID-19, uses the host endolysosomal
system for entry, replication, and egress. Previous studies have shown that the SARS-CoV-2 …

Roles and functions of SARS-CoV-2 proteins in host immune evasion

F Rashid, Z **e, M Suleman, A Shah, S Khan… - Frontiers in …, 2022 - frontiersin.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) evades the host immune
system through a variety of regulatory mechanisms. The genome of SARS-CoV-2 encodes …

Evolutionary trajectory of SARS-CoV-2 and emerging variants

J Singh, P Pandit, AG McArthur, A Banerjee… - Virology journal, 2021 - Springer
The emergence of a novel coronavirus, severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), and more recently, the independent evolution of multiple SARS-CoV-2 …

Understanding the role of SARS-CoV-2 ORF3a in viral pathogenesis and COVID-19

J Zhang, A Ejikemeuwa, V Gerzanich, M Nasr… - Frontiers in …, 2022 - frontiersin.org
The ongoing SARS-CoV-2 pandemic has shocked the world due to its persistence, COVID-
19-related morbidity and mortality, and the high mutability of the virus. One of the major …

The global epidemic of SARS‐CoV‐2 variants and their mutational immune escape

D Tian, YH Sun, JM Zhou, Q Ye - Journal of medical virology, 2022 - Wiley Online Library
During the COVID‐19 pandemic, genetic variants of SARS‐CoV‐2 have been emerging and
spreading around the world. Several SARS‐CoV‐2 endemic variants were found in United …

The role of cell death in SARS-CoV-2 infection

C Yuan, Z Ma, J **e, W Li, L Su, G Zhang, J Xu… - Signal transduction and …, 2023 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), showing high
infectiousness, resulted in an ongoing pandemic termed coronavirus disease 2019 (COVID …