Biodistribution, clearance, and long‐term fate of clinically relevant nanomaterials
Realization of the immense potential of nanomaterials for biomedical applications will
require a thorough understanding of how they interact with cells, tissues, and organs. There …
require a thorough understanding of how they interact with cells, tissues, and organs. There …
Drug development for neurodevelopmental disorders: lessons learned from fragile X syndrome
EM Berry-Kravis, L Lindemann, AE Jønch… - Nature reviews Drug …, 2018 - nature.com
Neurodevelopmental disorders such as fragile X syndrome (FXS) result in lifelong cognitive
and behavioural deficits and represent a major public health burden. FXS is the most …
and behavioural deficits and represent a major public health burden. FXS is the most …
Modeling fragile X syndrome in the Fmr1 knockout mouse
TM Kazdoba, PT Leach, JL Silverman… - Intractable & rare …, 2014 - jstage.jst.go.jp
Summary Fragile X Syndrome (FXS) is a commonly inherited form of intellectual disability
and one of the leading genetic causes for autism spectrum disorder. Clinical symptoms of …
and one of the leading genetic causes for autism spectrum disorder. Clinical symptoms of …
Evaluation of an activities of daily living scale for adolescents and adults with developmental disabilities
BACKGROUND: Activity limitations are an important and useful dimension of disability, but
there are few validated measures of activity limitations for adolescents and adults with …
there are few validated measures of activity limitations for adolescents and adults with …
Updated report on tools to measure outcomes of clinical trials in fragile X syndrome
Abstract Objective Fragile X syndrome (FXS) has been the neurodevelopmental disorder
with the most active translation of preclinical breakthroughs into clinical trials. This process …
with the most active translation of preclinical breakthroughs into clinical trials. This process …
The fragile X syndrome–autism comorbidity: what do we really know?
Autism spectrum disorder (ASD) is a common comorbid condition in people with fragile X
syndrome (FXS). It has been assumed that ASD symptoms reflect the same underlying …
syndrome (FXS). It has been assumed that ASD symptoms reflect the same underlying …
Improving IQ measurement in intellectual disabilities using true deviation from population norms
Background Intellectual disability (ID) is characterized by global cognitive deficits, yet the
very IQ tests used to assess ID have limited range and precision in this population …
very IQ tests used to assess ID have limited range and precision in this population …
The NIH Toolbox Cognitive Battery for intellectual disabilities: three preliminary studies and future directions
Background Recent advances in understanding molecular and synaptic mechanisms of
intellectual disabilities (ID) in fragile X syndrome (FXS) and Down syndrome (DS) through …
intellectual disabilities (ID) in fragile X syndrome (FXS) and Down syndrome (DS) through …
Current opinions on the present and future use of functional near-infrared spectroscopy in psychiatry
Functional near-infrared spectroscopy (fNIRS) is an optical imaging technique for assessing
human brain activity by noninvasively measuring the fluctuation of cerebral oxygenated-and …
human brain activity by noninvasively measuring the fluctuation of cerebral oxygenated-and …
A neurodevelopmental survey of Angelman syndrome with genotype-phenotype correlations
JK Gentile, WH Tan, LT Horowitz… - … of Developmental & …, 2010 - journals.lww.com
Objective: Angelman syndrome (AS) is a neurodevelopmental disorder caused by a deletion
on chromosome 15, uniparental disomy, imprinting defect, or UBE3A mutation. It is …
on chromosome 15, uniparental disomy, imprinting defect, or UBE3A mutation. It is …