Mitochondria as a target of environmental toxicants

JN Meyer, MCK Leung, JP Rooney… - toxicological …, 2013 - academic.oup.com
Enormous strides have recently been made in our understanding of the biology and
pathobiology of mitochondria. Many diseases have been identified as caused by …

Recent advances in the role of mass spectrometry in the analysis of food: a review

SC Nwachukwu, GI Edo, AN Jikah, OL Emakpor… - Journal of Food …, 2024 - Springer
Mass spectrometry (MS) is an essential analytical technique in the scientific domains of
chemistry, biochemistry, pharmacy, medicine, and many others. The technique is centrally …

Integrating enzymatic self-assembly and mitochondria targeting for selectively killing cancer cells without acquired drug resistance

H Wang, Z Feng, Y Wang, R Zhou… - Journal of the American …, 2016 - ACS Publications
Targeting organelles by modulating the redox potential of mitochondria is a promising
approach to kill cancer cells that minimizes acquired drug resistance. However, it lacks …

Synergistic enzymatic and bioorthogonal reactions for selective prodrug activation in living systems

Q Yao, F Lin, X Fan, Y Wang, Y Liu, Z Liu… - Nature …, 2018 - nature.com
Adverse drug reactions (ADRs) restrict the maximum doses applicable in chemotherapy,
which leads to failure in cancer treatment. Various approaches, including nano-drug and …

Imaging enzyme-triggered self-assembly of small molecules inside live cells

Y Gao, J Shi, D Yuan, B Xu - Nature communications, 2012 - nature.com
Self-assembly of small molecules in water to form nanofibres, besides generating
sophisticated biomaterials, promises a simple system inside cells for regulating cellular …

Intranuclear nanoribbons for selective killing of osteosarcoma cells

S Liu, Q Zhang, H He, M Yi, W Tan… - Angewandte Chemie …, 2022 - Wiley Online Library
Herein, we show intranuclear nanoribbons formed upon dephosphorylation of leucine‐rich L‐
or D‐phosphopeptide catalyzed by alkaline phosphatase (ALP) to selectively kill …

Comparative cytotoxicity of fourteen trivalent and pentavalent arsenic species determined using real-time cell sensing

B Moe, H Peng, X Lu, B Chen, LWL Chen… - Journal of …, 2016 - Elsevier
The occurrence of a large number of diverse arsenic species in the environment and in
biological systems makes it important to compare their relative toxicity. The toxicity of arsenic …

Arsenic and cancer: Evidence and mechanisms

RM Speer, X Zhou, LB Volk, KJ Liu… - Advances in pharmacology, 2023 - Elsevier
Arsenic is a potent carcinogen and poses a significant health concern worldwide. Exposure
occurs through ingestion of drinking water and contaminated foods and through inhalation …

A review on environmental factors regulating arsenic methylation in humans

CH Tseng - Toxicology and applied pharmacology, 2009 - Elsevier
Subjects exposed to arsenic show significant inter-individual variation in urinary patterns of
arsenic metabolites but insignificant day-to-day intra-individual variation. The inter-individual …

Origins, fate, and actions of methylated trivalent metabolites of inorganic arsenic: progress and prospects

M Stýblo, A Venkatratnam, RC Fry, DJ Thomas - Archives of toxicology, 2021 - Springer
The toxic metalloid inorganic arsenic (iAs) is widely distributed in the environment. Chronic
exposure to iAs from environmental sources has been linked to a variety of human diseases …