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[HTML][HTML] Final report of the phase I/II clinical trial of the E75 (nelipepimut-S) vaccine with booster inoculations to prevent disease recurrence in high-risk breast cancer …
EA Mittendorf, GT Clifton, JP Holmes, E Schneble… - Annals of oncology, 2014 - Elsevier
ABSTRACT Background E75 (nelipepimut-S) is a human leukocyte antigen (HLA)-A2/A3-
restricted immunogenic peptide derived from the HER2 protein. We have conducted phase …
restricted immunogenic peptide derived from the HER2 protein. We have conducted phase …
Targeting tumor vasculature with TNF leads effector T cells to the tumor and enhances therapeutic efficacy of immune checkpoint blockers in combination with …
Purpose: Irregular blood flow and endothelial cell anergy, which characterize many solid
tumors, hinder tumor infiltration by cytotoxic T lymphocytes (CTL). This confers resistance to …
tumors, hinder tumor infiltration by cytotoxic T lymphocytes (CTL). This confers resistance to …
The dark side of dendritic cells: development and exploitation of tolerogenic activity that favor tumor outgrowth and immune escape
Dendritic cells (DC) play a central role in the regulation of the immune responses by
providing the information needed to decide between tolerance, ignorance, or active …
providing the information needed to decide between tolerance, ignorance, or active …
Inefficacy of therapeutic cancer vaccines and proposed improvements. Casus of prostate cancer
Prophylactic vaccination is arguably the most effective medical preventative method. After
local inoculation, vaccines induce antigen-specific systemic immunity, protecting the whole …
local inoculation, vaccines induce antigen-specific systemic immunity, protecting the whole …
Dendritic cell regulation of NK‐cell responses involves lymphotoxin‐α, IL‐12, and TGF‐β
Dendritic cell (DC) vaccines induce T‐cell responses in cancer patients. However, there is a
paucity of data regarding the role of DC vaccines in sha** natural killer (NK) cell …
paucity of data regarding the role of DC vaccines in sha** natural killer (NK) cell …
Prophylactic dendritic cell-based vaccines efficiently inhibit metastases in murine metastatic melanoma
OV Markov, NL Mironova, SV Sennikov, VV Vlassov… - PLoS …, 2015 - journals.plos.org
Recent data on the application of dendritic cells (DCs) as anti-tumor vaccines has shown
their great potential in therapy and prophylaxis of cancer. Here we report on a comparison of …
their great potential in therapy and prophylaxis of cancer. Here we report on a comparison of …
Induction of T-cell memory by a dendritic cell vaccine: a computational model
Motivation: Although results from phase III clinical trials substantially support the use of
prophylactic and therapeutic vaccines against cancer, what has yet to be defined is how …
prophylactic and therapeutic vaccines against cancer, what has yet to be defined is how …
Immuno-kinetics of immunotherapy: dosing with DCs
Therapeutic vaccines play a large role in the cast of immunotherapies that are now an
essential component in most cancer treatment regimes. The complexity of the immune …
essential component in most cancer treatment regimes. The complexity of the immune …
Efficacy of Dendritic Cell-Based Immunotherapy Produced from Cord Blood in vitro and in a Humanized NSG Mouse Cancer Model
G Liu, X Fan, Y Cai, Z Fu, F Gao, J Dong, K Li… - Immunotherapy, 2019 - Taylor & Francis
Aim: To produce dendritic cells (DCs) from CD34+ stem cells from cord blood and explore
their prophylactic and curative effect against tumors by vaccinating humanized NSG mice …
their prophylactic and curative effect against tumors by vaccinating humanized NSG mice …
Dendritic cells pulsed with tumor cells killed by high hydrostatic pressure inhibit prostate tumor growth in TRAMP mice
R Mikyskova, M Indrova, I Stepanek, I Kanchev… - …, 2017 - Taylor & Francis
Dendritic cell (DC)-based vaccines pulsed with high hydrostatic pressure (HHP)-inactivated
tumor cells have recently been shown to be a promising tool for prostate cancer …
tumor cells have recently been shown to be a promising tool for prostate cancer …