Functional hydrogels for the treatment of myocardial infarction

T Wu, W Liu - NPG Asia Materials, 2022 - nature.com
Myocardial infarction (MI) is a major disease posing a significant threat to human health, as it
leads to necrosis of numerous cardiomyocytes (CMs), left ventricle dilation, and cardiac …

Immunomodulatory functions of mesenchymal stem cells in tissue engineering

H Li, S Shen, H Fu, Z Wang, X Li, X Sui… - Stem cells …, 2019 - Wiley Online Library
The inflammatory response to chronic injury affects tissue regeneration and has become an
important factor influencing the prognosis of patients. In previous stem cell treatments, it was …

[HTML][HTML] Acellular cardiac scaffolds enriched with MSC-derived extracellular vesicles limit ventricular remodelling and exert local and systemic immunomodulation in a …

M Monguió-Tortajada, C Prat-Vidal… - Theranostics, 2022 - ncbi.nlm.nih.gov
Abstract Rationale: Extracellular vesicles (EVs) from mesenchymal stromal cell (MSC) are a
potential therapy for cardiac healing after myocardial infarction (MI). Nevertheless, neither …

Immunomodulatory biomaterials and their application in therapies for chronic inflammation-related diseases

JR Nakkala, Z Li, W Ahmad, K Wang, C Gao - Acta Biomaterialia, 2021 - Elsevier
The degree of tissue injuries such as the level of scarring or organ dysfunction, and the
immune response against them primarily determine the outcome and speed of healing …

Cell type-and tissue-specific functions of ecto-5′-nucleotidase (CD73)

M Minor, KP Alcedo, RA Battaglia… - American Journal of …, 2019 - journals.physiology.org
Ecto-5′-nucleotidase [cluster of differentiation 73 (CD73)] is a ubiquitously expressed
glycosylphosphatidylinositol-anchored glycoprotein that converts extracellular adenosine …

CD73 expression on mesenchymal stem cells dictates the reparative properties via its anti‐inflammatory activity

K Tan, H Zhu, J Zhang, W Ouyang, J Tang… - Stem cells …, 2019 - Wiley Online Library
Mesenchymal stem cells (MSC) are not universal and may be subject to dynamic changes
upon local milieus in vivo and after isolation and cultivation in vitro. Here, we demonstrate …

Hydrogel encapsulation: Taking the therapy of mesenchymal stem cells and their derived secretome to the next level

Y Huang, X Li, L Yang - Frontiers in Bioengineering and …, 2022 - frontiersin.org
Biomaterials have long been the focus of research and hydrogels are representatives
thereof. Hydrogels have attracted much attention in the medical sciences, especially as a …

Cellular mechanisms and pathways in myocardial reperfusion injury

I Valikeserlis, AA Athanasiou, D Stakos - Coronary Artery Disease, 2021 - journals.lww.com
Despite the progress of cardiovascular medicine, ischemia-reperfusion injury can contribute
to increased mortality and prolonged hospitalization after myocardial infarction. Ischemia …

Mesenchymal stem cells and their exocytotic vesicles

H Cai, H Guo - International Journal of Molecular Sciences, 2023 - mdpi.com
Mesenchymal stem cells (MSCs), as a kind of pluripotent stem cells, have attracted much
attention in orthopedic diseases, geriatric diseases, metabolic diseases, and sports …

Enhancement of functionality and therapeutic efficacy of cell-based therapy using mesenchymal stem cells for cardiovascular disease

CW Yun, SH Lee - International journal of molecular sciences, 2019 - mdpi.com
Cardiovascular disease usually triggers coronary heart disease, stroke, and ischemic
diseases, thus promoting the development of functional failure. Mesenchymal stem cells …