[HTML][HTML] Mechanisms and regulation of replication fork reversal
DNA replication is remarkably accurate with estimates of only a handful of mutations per
human genome per cell division cycle. Replication stress caused by DNA lesions …
human genome per cell division cycle. Replication stress caused by DNA lesions …
(Single-stranded DNA) gaps in understanding BRCAness
A Schreuder, TJ Wendel, CGV Dorresteijn… - Trends in Genetics, 2024 - cell.com
The tumour-suppressive roles of BRCA1 and 2 have been attributed to three seemingly
distinct functions–homologous recombination, replication fork protection, and single …
distinct functions–homologous recombination, replication fork protection, and single …
Long-molecule scars of backup DNA repair in BRCA1-and BRCA2-deficient cancers
Homologous recombination (HR) deficiency is associated with DNA rearrangements and
cytogenetic aberrations. Paradoxically, the types of DNA rearrangements that are …
cytogenetic aberrations. Paradoxically, the types of DNA rearrangements that are …
Stressed? Break-induced replication comes to the rescue!
Break-induced replication (BIR) is a homologous recombination (HR) pathway that repairs
one-ended DNA double-strand breaks (DSBs), which can result from replication fork …
one-ended DNA double-strand breaks (DSBs), which can result from replication fork …
Homologous recombination as a fundamental genome surveillance mechanism during DNA replication
J Spies, H Polasek-Sedlackova, J Lukas, K Somyajit - Genes, 2021 - mdpi.com
Accurate and complete genome replication is a fundamental cellular process for the proper
transfer of genetic material to cell progenies, normal cell growth, and genome stability …
transfer of genetic material to cell progenies, normal cell growth, and genome stability …
FANCM branchpoint translocase: Master of traverse, reverse and adverse DNA repair
FANCM is a multifunctional DNA repair enzyme that acts as a sensor and coordinator of
replication stress responses, especially interstrand crosslink (ICL) repair mediated by the …
replication stress responses, especially interstrand crosslink (ICL) repair mediated by the …
RAD51 paralogs: expanding roles in replication stress responses and repair
D Bhattacharya, S Sahoo, T Nagraj, S Dixit… - Current Opinion in …, 2022 - Elsevier
Mammalian RAD51 paralogs are essential for cell survival and are critical for RAD51-
mediated repair of DNA double-strand breaks (DSBs) by homologous recombination (HR) …
mediated repair of DNA double-strand breaks (DSBs) by homologous recombination (HR) …
Chromosomal breaks at the origin of small tandem DNA duplications
J Schimmel, MD van Wezel, R van Schendel… - …, 2023 - Wiley Online Library
Small tandem DNA duplications in the range of 15 to 300 base‐pairs play an important role
in the aetiology of human disease and contribute to genome diversity. Here, we discuss …
in the aetiology of human disease and contribute to genome diversity. Here, we discuss …
Mechanisms of tandem duplication in the cancer genome
Tandem duplications (TD) are among the most frequent type of structural variant (SV) in the
cancer genome. They are characterized by a single breakpoint junction that defines the …
cancer genome. They are characterized by a single breakpoint junction that defines the …
Rad51-mediated replication of damaged templates relies on monoSUMOylated DDK kinase
DNA damage tolerance (DDT), activated by replication stress during genome replication, is
mediated by translesion synthesis and homologous recombination (HR). Here we uncover …
mediated by translesion synthesis and homologous recombination (HR). Here we uncover …