The mammalian ionotropic glutamate receptor family encodes 18 gene products that
coassemble to form ligand-gated ion channels containing an agonist recognition site, a …

The past two decades have witnessed a dramatic accumulation of evidence indicating that
the excitatory amino acid glutamate plays an important role in drug addiction and …

Adaptation of the nervous system to different chemical and physiologic conditions is
important for the homeostasis of brain processes and for learning and remembering …

Alcohol acts on numerous cellular and molecular targets to regulate neuronal
communication within the brain. Chronic alcohol exposure and acute withdrawal generate …

Recent advances in neuroscience have made it possible to investigate the pathophysiology
of alcoholism at a cellular and molecular level. Evidence indicates that ethanol affects …

Previous studies have shown that ethanol inhibits memory‐related synaptic activity and
plasticity more potently in hippocampal slices from immature rats, compared with those …

Ethanol (EtOH) has effects on numerous cellular molecular targets, and alterations in
synaptic function are prominent among these effects. Acute exposure to EtOH activates or …

Alcoholism is associated with acute and long-term cognitive dysfunction including memory
impairment, resulting in substantial disability and cost to society. Thus, understanding how …

OBJECTIVE: To describe the change of pain reports over time in 3 cohorts derived from the
general population:(1) no chronic pain (NCP; n= 1156);(2) chronic regional pain (CRP; n …

Publisher Summary This chapter discusses the effect of ethanol on ion channels. Ion
channels play critical roles in nervous system function from initiating rapid synaptic activity to …