The epithelial–mesenchymal plasticity landscape: principles of design and mechanisms of regulation
Epithelial–mesenchymal plasticity (EMP) enables cells to interconvert between several
states across the epithelial–mesenchymal landscape, thereby acquiring hybrid epithelial …
states across the epithelial–mesenchymal landscape, thereby acquiring hybrid epithelial …
Epidemiology and genomics of prostate cancer in Asian men
Prostate cancer is a global health problem, but incidence varies considerably across
different continents. Asia is traditionally considered a low-incidence area, but the incidence …
different continents. Asia is traditionally considered a low-incidence area, but the incidence …
Targeting signaling pathways in prostate cancer: mechanisms and clinical trials
Prostate cancer (PCa) affects millions of men globally. Due to advances in understanding
genomic landscapes and biological functions, the treatment of PCa continues to improve …
genomic landscapes and biological functions, the treatment of PCa continues to improve …
Multi-tiered chemical proteomic maps of tryptoline acrylamide–protein interactions in cancer cells
E Njomen, RE Hayward, KE DeMeester… - Nature …, 2024 - nature.com
Covalent chemistry is a versatile approach for expanding the ligandability of the human
proteome. Activity-based protein profiling (ABPP) can infer the specific residues modified by …
proteome. Activity-based protein profiling (ABPP) can infer the specific residues modified by …
SETD7 functions as a transcription repressor in prostate cancer via methylating FOXA1
Dysregulation of histone lysine methyltransferases and demethylases is one of the major
mechanisms driving the epigenetic reprogramming of transcriptional networks in castration …
mechanisms driving the epigenetic reprogramming of transcriptional networks in castration …
Epigenomic heterogeneity as a source of tumour evolution
In the past decade, remarkable progress in cancer medicine has been achieved by the
development of treatments that target DNA sequence variants. However, a purely genetic …
development of treatments that target DNA sequence variants. However, a purely genetic …
Molecular mechanisms underlying the development of neuroendocrine prostate cancer
Prostate cancer is the most common non-cutaneous cancer and the second leading cause
of cancer-associated deaths among men in the United States. Androgen deprivation therapy …
of cancer-associated deaths among men in the United States. Androgen deprivation therapy …
FOXA1 O-GlcNAcylation–mediated transcriptional switch governs metastasis capacity in breast cancer
Y Liu, K Yu, X Kong, K Zhang, L Wang, N Zhang… - Science …, 2023 - science.org
FOXA1, a transcription factor involved in epigenetic reprogramming, is crucial for breast
cancer progression. However, the mechanisms by which FOXA1 achieves its oncogenic …
cancer progression. However, the mechanisms by which FOXA1 achieves its oncogenic …
Nucleic-acid-based targeted degradation in drug discovery
W Wang, S He, G Dong, C Sheng - Journal of Medicinal Chemistry, 2022 - ACS Publications
Targeted protein degradation (TPD), represented by proteolysis-targeting chimera
(PROTAC), has emerged as a novel therapeutic modality in drug discovery. However, the …
(PROTAC), has emerged as a novel therapeutic modality in drug discovery. However, the …
hsa_circ_0007919 induces LIG1 transcription by binding to FOXA1/TET1 to enhance the DNA damage response and promote gemcitabine resistance in pancreatic …
L Xu, X Ma, X Zhang, C Zhang, Y Zhang, S Gong… - Molecular Cancer, 2023 - Springer
Abstract Background Circular RNAs (circRNAs) play important roles in the occurrence and
development of cancer and chemoresistance. DNA damage repair contributes to the …
development of cancer and chemoresistance. DNA damage repair contributes to the …