A general consensus exists that IBD is associated with compositional and metabolic
changes in the intestinal microbiota (dysbiosis). However, a direct causal relationship …

The gut microbiota, the largest symbiotic ecosystem with the host, has been shown to play
important roles in maintaining intestinal homeostasis. Dysbiosis of the gut microbiome is …

Microbiota are thought to influence the development and progression of inflammatory bowel
disease (IBD), but determining generalizable effects of microbiota on IBD etiology requires …

Abstract T helper 17 (TH17) cells have been extensively studied since their discovery 10
years ago, primarily because of their known pathogenic role in many inflammatory diseases …

Experimental mouse models are central to basic biomedical research; however, variability
exists across genetically identical mice and mouse facilities making comparisons difficult …

Inflammatory bowel disease (IBD) is a complex set of diseases that lead to chronic
inflammation in the gastrointestinal tract. Although the etiology of IBD is not fully understood …

Specific members of the intestinal microbiota dramatically affect inflammatory bowel disease
(IBD) in mice. In humans, however, identifying bacteria that preferentially affect disease …

Commensal bacteria inhabit mucosal and epidermal surfaces in mice and humans, and
have effects on metabolic and immune pathways in their hosts. Recent studies indicate that …

T-helper 17 (Th17) and T-regulatory (Treg) cells are frequently found at barrier surfaces,
particularly within the intestinal mucosa, where they function to protect the host from …

Gut microbiota is an assortment of microorganisms inhabiting the length and width of the
mammalian gastrointestinal tract. The composition of this microbial community is host …