A myriad of environmental and genetic factors, as well as the physiologic process of aging,
contribute to Alzheimer's disease (AD) pathology. Neuroinflammation is and has been a …

All over the world, metabolic syndrome constitutes severe health problems. Multiple factors
have been reported in the pathogenesis of metabolic syndrome. Metabolic disorders result …

Oxidative stress and energy imbalance strongly correlate in neurodegenerative diseases.
Repeated concussion is becoming a serious public health issue with uncontrollable adverse …

The post-injury inflammatory response is a key mediator in long-term recovery from
traumatic brain injury (TBI). Moreover, the immune response to TBI, mediated by microglia …

The receptor for advanced glycation end products (RAGE), a pattern recognition receptor
signaling event, has been associated with several human illnesses, including …

Microglia plays a critical role in the brain and protects neuronal cells from toxins. However,
over-activation of microglia leads to deleterious effects. Lipopolysaccharide (LPS) has been …

Oxidative stress has been considered the main mediator in neurodegenerative disease and
in normal aging processes. Several studies have reported that the accumulation of reactive …

The aim of the current study was to explore the underlying neuroprotective mechanisms of
curcumin (50 mg/kg, for six weeks) against ethanol (5 mg/kg ip, for six weeks) induced …

Heavy metals such as lead, cadmium, mercury, and arsenic are prevalent in the
environment due to both natural and anthropogenic sources, leading to significant public …

Background Glycine is the smallest nonessential amino acid and has previously
unrecognized neurotherapeutic effects. In this study, we examined the mechanism …