Therapeutic targeting of repurposed anticancer drugs in Alzheimer's disease: Using the multiomics approach
Aim/Hypothesis: The complexity and heterogeneity of multiple pathological features make
Alzheimer's disease (AD) a major culprit to global health. Drug repurposing is an …
Alzheimer's disease (AD) a major culprit to global health. Drug repurposing is an …
Multi-omics data integration and network-based analysis drives a multiplex drug repurposing approach to a shortlist of candidate drugs against COVID-19
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic is
undeniably the most severe global health emergency since the 1918 Influenza outbreak …
undeniably the most severe global health emergency since the 1918 Influenza outbreak …
Molecular taxonomy of systemic lupus erythematosus through data-driven patient stratification: molecular endotypes and cluster-tailored drugs
P Garantziotis, D Nikolakis, S Doumas… - Frontiers in …, 2022 - frontiersin.org
Objectives Treatment of Systemic Lupus Erythematosus (SLE) is characterized by a largely
empirical approach and relative paucity of novel compound development. We sought to …
empirical approach and relative paucity of novel compound development. We sought to …
[HTML][HTML] Network-based stage-specific drug repurposing for Alzheimer's disease
Alzheimer's disease (AD) is a progressive neurodegenerative disease and the most
common type of dementia. With no disease-curing drugs available and an ever-growing AD …
common type of dementia. With no disease-curing drugs available and an ever-growing AD …
Sirolimus as a repurposed drug for tendinopathy: A systems biology approach combining computational and experimental methods
Z Wang, J Luo, L Jiang, C Tang, Y Chen, K Yang… - Computers in Biology …, 2025 - Elsevier
Background Effective drugs for tendinopathy are lacking, resulting in significant morbidity
and re-tearing rate after operation. Applying systems biology to identify new applications for …
and re-tearing rate after operation. Applying systems biology to identify new applications for …
Fibrotic expression profile analysis reveals repurposed drugs with potential anti-fibrotic mode of action
Fibrotic diseases cover a spectrum of systemic and organ-specific maladies that affect a
large portion of the population, currently without cure. The shared characteristic these …
large portion of the population, currently without cure. The shared characteristic these …
Deciphering the molecular mechanism and crosstalk between Parkinson's disease and breast cancer through multi-omics and drug repurposing approach
Epidemiological studies indicate a higher occurrence of breast cancer (BRCA) in patients
with Parkinson's disease. However, the exact molecular mechanism is still not precise …
with Parkinson's disease. However, the exact molecular mechanism is still not precise …
Integrating transcriptomics and network analysis-based multiplexed drug repurposing to screen drug candidates for M2 macrophage-associated castration-resistant …
J Chang, Z Jiang, T Ma, J Li, J Chen, P Ye… - Frontiers in …, 2022 - frontiersin.org
Metastatic castration-resistant prostate cancer (CRPC) has long been considered to be
associated with patient mortality. Among metastatic organs, bone is the most common …
associated with patient mortality. Among metastatic organs, bone is the most common …
[HTML][HTML] DTA Atlas: A massive-scale drug repurposing database
M Sultanova, E Vinogradova, A Amantay… - Artificial Intelligence in …, 2024 - Elsevier
The drug development process is costly and time-consuming. Repurposing existing
approved drugs, an efficient and cost-effective strategy, involves assessing numerous drug …
approved drugs, an efficient and cost-effective strategy, involves assessing numerous drug …
Dissecting the functional significance of HSP90AB1 and other heat shock proteins in countering glioblastomas and ependymomas using omics analysis and drug …
Heat shock proteins (HSPs) are the evolutionary family of proteins that are highly conserved
and present widely in various organisms and play an array of important roles and cellular …
and present widely in various organisms and play an array of important roles and cellular …