Cell culture is a widely used in vitro tool for improving our understanding of cell biology,
tissue morphology, and mechanisms of diseases, drug action, protein production and the …

Proton therapy treatments are based on a proton RBE (relative biological effectiveness)
relative to high-energy photons of 1.1. The use of this generic, spatially invariant RBE within …

The past 20 years have seen dramatic changes in the delivery of radiation therapy, but the
impact of radiobiology on the clinic has been far less substantial. A major consideration in …

Aging is an inevitable process of life. Defined by progressive physiological and functional
loss of tissues and organs, aging increases the risk of mortality for the organism. The aging …

Interlocking gene mutations, epigenetic alterations and microenvironmental features
perpetuate tumor development, growth, infiltration and spread. Consequently, intrinsic and …

Introduction Of the more than one million global cases of breast cancer diagnosed each
year, approximately fifteen percent are characterized as triple-negative, lacking the …

The hallmarks of cancer capture the most essential phenotypic characteristics of malignant
transformation and progression. Although numerous factors involved in this multi-step …

Background. Glioblastoma (GBM) is the most common primary brain tumor, with dismal
prognosis. The failure of drug–radiation combinations with promising preclinical data to …

Double-strand DNA breaks (DSBs) continuously arise and cause mutations and
chromosomal rearrangements. Here, we present DSBCapture, a sequencing-based method …

Life science research focuses on deciphering the biochemical mechanisms that regulate cell
proliferation and function and largely depends on the use of tissue culture methods in which …