Animal seizure and epilepsy models continue to play an important role in the early discovery
of new therapies for the symptomatic treatment of epilepsy. Since 1937, with the discovery of …

Intestinal metabolism can limit oral bioavailability of drugs and increase the risk of drug
interactions. It is therefore important to be able to predict and quantify it in drug discovery …

Reflecting more than a decade's worth of changes, Animal Models in Toxicology, Second
Edition is a practical guide to the common statistical problems encountered in toxicology and …

Chimeric antigen receptor (CAR) T cells form part of a broad wave of immunotherapies that
are showing promise in early phase cancer clinical trials. This clinical delivery has been …

Cytochrome P450 proteins (CYP450s) are present in most domains of life and play a critical
role in the metabolism of endogenous compounds and xenobiotics. The effects of exposure …

We aimed to develop a mouse model of polypharmacy, primarily to establish whether short-
term exposure to polypharmacy causes adverse geriatric outcomes. We also investigated …

Famoxadone is a chiral fungicide frequently found in the environment and agricultural
products. However, the health risks of famoxadone enantiomers are not well understood …

There is a significant need for in vitro methods to study drug-induced liver injury that are
rapid, reproducible, and scalable for existing high-throughput systems. However, traditional …

ABSTRACT APX001 is a first-in-class, intravenous and orally available, broad-spectrum
antifungal agent in clinical development for the treatment of life-threatening invasive fungal …

Drug-induced liver injury (DILI) represents a major impediment to the development of new
drugs and is a leading cause of drug withdrawal. The occurrence of hepatotoxicity has been …