Rhodanine as a scaffold in drug discovery: a critical review of its biological activities and mechanisms of target modulation
Introduction: Rhodanine-based compounds have been associated with numerous biological
activities. After many years of research in drug discovery, they have gained a reputation as …
activities. After many years of research in drug discovery, they have gained a reputation as …
[HTML][HTML] Regulation and involvement of matrix metalloproteinases in vascular diseases
Matrix metalloproteinases (MMPs) are a family of zinc dependent endopeptidases whose
main function is to degrade and deposit structural proteins within the extracellular matrix …
main function is to degrade and deposit structural proteins within the extracellular matrix …
Discovery and Mechanistic Studies of Dual-Target Hits for Carbonic Anhydrase IX and VEGFR-2 as Potential Agents for Solid Tumors: X-ray, In Vitro, In Vivo, and In …
A dual-targeting approach is predicted to yield better cancer therapy outcomes.
Consequently, a series of coumarin-based thiazoles (5a–h, 6, and 7a–e) were designed and …
Consequently, a series of coumarin-based thiazoles (5a–h, 6, and 7a–e) were designed and …
[HTML][HTML] Structure-based molecular modeling in SAR analysis and lead optimization
In silico methods like molecular docking and pharmacophore modeling are established
strategies in lead identification. Their successful application for finding new active molecules …
strategies in lead identification. Their successful application for finding new active molecules …
Recent research advances in selective matrix metalloproteinase‐13 inhibitors as anti‐osteoarthritis agents
XW **e, RZ Wan, ZP Liu - ChemMedChem, 2017 - Wiley Online Library
Abstract Matrix metalloproteinase‐13 (MMP‐13) plays a key role in the degradation of type II
collagen in cartilage and bone in osteoarthritis (OA). The subtle differences between the …
collagen in cartilage and bone in osteoarthritis (OA). The subtle differences between the …
Selective MMP-13 inhibitors: promising agents for the therapy of osteoarthritis
Y Wan, W Li, Z Liao, M Yan, X Chen… - Current medicinal …, 2020 - ingentaconnect.com
Osteoarthritis (OA) is an age-related degenerative disease, which is characterized by
chronic joint pain, inflammation and the damage of joint cartilage. At present, steroidal drugs …
chronic joint pain, inflammation and the damage of joint cartilage. At present, steroidal drugs …
Fragment-based design and synthesis of coumarin-based thiazoles as dual c-MET/STAT-3 inhibitors for potential antitumor agents
Abstract c-MET and STAT-3 are significant targets for cancer treatments. Here, we describe
a class of very effective dual STAT-3 and c-MET inhibitors with coumarin-based thiazoles …
a class of very effective dual STAT-3 and c-MET inhibitors with coumarin-based thiazoles …
3-(Bromoacetyl) coumarins: unraveling their synthesis, chemistry, and applications
This review emphasizes recent developments in synthetic routes of 3-(bromoacetyl)
coumarin derivatives. Also, chemical reactions of 3-(bromoacetyl) coumarins as versatile …
coumarin derivatives. Also, chemical reactions of 3-(bromoacetyl) coumarins as versatile …
In vitro and in vivo trypanocidal activities of 8‐methoxy‐3‐(4‐nitrobenzoyl)‐6‐propyl‐2H‐cromen‐2‐one, a new synthetic coumarin of low cytotoxicity against …
GA Brancaglion, AE Toyota… - Chemical biology & …, 2018 - Wiley Online Library
Natural and synthetic coumarins have been described as prototypes of new drug candidates
against Chagas' disease. During a typical screening with new compounds, we observed the …
against Chagas' disease. During a typical screening with new compounds, we observed the …
Randomized controlled studies on the efficacy of antiarthritic agents in inhibiting cartilage degeneration and pain associated with progression of osteoarthritis in the rat
EM TenBroek, L Yunker, MF Nies… - Arthritis research & …, 2016 - Springer
Background As an initial step in the development of a local therapeutic to treat osteoarthritis
(OA), a number of agents were tested for their ability to block activation of inflammation …
(OA), a number of agents were tested for their ability to block activation of inflammation …