LPA receptor signaling: pharmacology, physiology, and pathophysiology

YC Yung, NC Stoddard, J Chun - Journal of lipid research, 2014 - ASBMB
Lysophosphatidic acid (LPA) is a small ubiquitous lipid found in vertebrate and
nonvertebrate organisms that mediates diverse biological actions and demonstrates …

LPA receptors: subtypes and biological actions

JW Choi, DR Herr, K Noguchi, YC Yung… - Annual review of …, 2010 - annualreviews.org
Lysophosphatidic acid (LPA) is a small, ubiquitous phospholipid that acts as an extracellular
signaling molecule by binding to and activating at least five known G protein–coupled …

Lysophospholipid receptor nomenclature review: IUPHAR Review 8

Y Kihara, M Maceyka, S Spiegel… - British journal of …, 2014 - Wiley Online Library
Lysophospholipids encompass a diverse range of small, membrane‐derived phospholipids
that act as extracellular signals. The signalling properties are mediated by 7 …

Lysophosphatidic acid (LPA) receptors: signaling properties and disease relevance

ME Lin, DR Herr, J Chun - Prostaglandins & other lipid mediators, 2010 - Elsevier
Lysophosphatidic acid (LPA), a water-soluble phospholipid, has gained significant attention
in recent years since the discovery that it acts as a potent signaling molecule with wide …

Lysophospholipids and their receptors in the central nervous system

JW Choi, J Chun - Biochimica et Biophysica Acta (BBA)-Molecular and …, 2013 - Elsevier
Lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P), two of the best-studied
lysophospholipids, are known to influence diverse biological events, including organismal …

Crystal structure of antagonist bound human lysophosphatidic acid receptor 1

JE Chrencik, CB Roth, M Terakado, H Kurata, R Omi… - Cell, 2015 - cell.com
Lipid biology continues to emerge as an area of significant therapeutic interest, particularly
as the result of an enhanced understanding of the wealth of signaling molecules with …

Secret talk between adipose tissue and central nervous system via secreted factors—an emerging frontier in the neurodegenerative research

A Parimisetty, AC Dorsemans, R Awada… - Journal of …, 2016 - Springer
First seen as a storage organ, the white adipose tissue (WAT) is now considered as an
endocrine organ. WAT can produce an array of bioactive factors known as adipokines acting …

Autotaxin and LPA receptor signaling in cancer

AJS Houben, WH Moolenaar - Cancer and Metastasis Reviews, 2011 - Springer
Lysophosphatidic acid (LPA; monoacyl-glycerol-3-phosphate) is a lipid mediator that
functions as a mitogen and motility factor for many cell types. LPA signals through six …

Insights into autotaxin: how to produce and present a lipid mediator

WH Moolenaar, A Perrakis - Nature reviews Molecular cell biology, 2011 - nature.com
Autotaxin (ATX) is a secreted phosphodiesterase that produces the lipid mediator
lysophosphatidic acid (LPA). LPA acts through specific guanine-nucleotide-binding protein …

Lysophosphatidic acid (LPA) and its receptors

K Noguchi, D Herr, T Mutoh, J Chun - Current opinion in pharmacology, 2009 - Elsevier
Lysophosphatidic acid (LPA), a bioactive phospholipid, and its family of cognate G protein-
coupled receptors have demonstrated roles in many biological functions in the nervous …