LPA receptor signaling: pharmacology, physiology, and pathophysiology
Lysophosphatidic acid (LPA) is a small ubiquitous lipid found in vertebrate and
nonvertebrate organisms that mediates diverse biological actions and demonstrates …
nonvertebrate organisms that mediates diverse biological actions and demonstrates …
LPA receptors: subtypes and biological actions
Lysophosphatidic acid (LPA) is a small, ubiquitous phospholipid that acts as an extracellular
signaling molecule by binding to and activating at least five known G protein–coupled …
signaling molecule by binding to and activating at least five known G protein–coupled …
Lysophospholipid receptor nomenclature review: IUPHAR Review 8
Lysophospholipids encompass a diverse range of small, membrane‐derived phospholipids
that act as extracellular signals. The signalling properties are mediated by 7 …
that act as extracellular signals. The signalling properties are mediated by 7 …
Lysophosphatidic acid (LPA) receptors: signaling properties and disease relevance
Lysophosphatidic acid (LPA), a water-soluble phospholipid, has gained significant attention
in recent years since the discovery that it acts as a potent signaling molecule with wide …
in recent years since the discovery that it acts as a potent signaling molecule with wide …
Lysophospholipids and their receptors in the central nervous system
Lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P), two of the best-studied
lysophospholipids, are known to influence diverse biological events, including organismal …
lysophospholipids, are known to influence diverse biological events, including organismal …
Crystal structure of antagonist bound human lysophosphatidic acid receptor 1
JE Chrencik, CB Roth, M Terakado, H Kurata, R Omi… - Cell, 2015 - cell.com
Lipid biology continues to emerge as an area of significant therapeutic interest, particularly
as the result of an enhanced understanding of the wealth of signaling molecules with …
as the result of an enhanced understanding of the wealth of signaling molecules with …
Secret talk between adipose tissue and central nervous system via secreted factors—an emerging frontier in the neurodegenerative research
A Parimisetty, AC Dorsemans, R Awada… - Journal of …, 2016 - Springer
First seen as a storage organ, the white adipose tissue (WAT) is now considered as an
endocrine organ. WAT can produce an array of bioactive factors known as adipokines acting …
endocrine organ. WAT can produce an array of bioactive factors known as adipokines acting …
Autotaxin and LPA receptor signaling in cancer
AJS Houben, WH Moolenaar - Cancer and Metastasis Reviews, 2011 - Springer
Lysophosphatidic acid (LPA; monoacyl-glycerol-3-phosphate) is a lipid mediator that
functions as a mitogen and motility factor for many cell types. LPA signals through six …
functions as a mitogen and motility factor for many cell types. LPA signals through six …
Insights into autotaxin: how to produce and present a lipid mediator
Autotaxin (ATX) is a secreted phosphodiesterase that produces the lipid mediator
lysophosphatidic acid (LPA). LPA acts through specific guanine-nucleotide-binding protein …
lysophosphatidic acid (LPA). LPA acts through specific guanine-nucleotide-binding protein …
Lysophosphatidic acid (LPA) and its receptors
Lysophosphatidic acid (LPA), a bioactive phospholipid, and its family of cognate G protein-
coupled receptors have demonstrated roles in many biological functions in the nervous …
coupled receptors have demonstrated roles in many biological functions in the nervous …