Globally, 50 million people live with dementia, with Alzheimer disease (AD) being
responsible for two-thirds of the total cases. As ageing is the main risk factor for dementia …

The symptoms of Alzheimer disease reflect a loss of neural circuit integrity in the brain, but
neurons do not work in isolation. Emerging evidence suggests that the intricate balance of …

APOE4 is the strongest genetic risk factor for Alzheimer's disease,–. However, the effects of
APOE4 on the human brain are not fully understood, limiting opportunities to develop …

The incidence of Alzheimer's disease (AD), the leading cause of dementia, increases rapidly
with age, but why age constitutes the main risk factor is still poorly understood. Brain ageing …

Alzheimer's disease (AD) is the leading cause of dementia in older adults. Although AD
progression is characterized by stereotyped accumulation of proteinopathies, the affected …

Abstract Apolipoprotein E4 (APOE4) is the strongest known genetic risk factor for late-onset
Alzheimer's disease (AD). Conditions of stress or injury induce APOE expression within …

Age-related myelin damage induces inflammatory responses, yet its involvement in
Alzheimer's disease remains uncertain, despite age being a major risk factor. Using a …

Alzheimer´ s disease (AD) stands out as the most common chronic neurodegenerative
disorder. AD is characterized by progressive cognitive decline and memory loss, with …

Abstract The Wisconsin Registry for Alzheimer's Prevention is a longitudinal observational
cohort study enriched with persons with a parental history (PH) of probable Alzheimer's …

Alzheimer's disease (AD) constitutes the most prominent form of dementia among elderly
individuals worldwide. Disease modeling using murine transgenic mice was first initiated …