Natural killer cell therapies

E Vivier, L Rebuffet, E Narni-Mancinelli, S Cornen… - Nature, 2024 - nature.com
Natural killer (NK) cells are lymphocytes of the innate immune system. A key feature of NK
cells is their ability to recognize a wide range of cells in distress, particularly tumour cells …

Exploring the NK cell platform for cancer immunotherapy

JA Myers, JS Miller - Nature reviews Clinical oncology, 2021 - nature.com
Natural killer (NK) cells are cytotoxic lymphocytes of the innate immune system that are
capable of killing virally infected and/or cancerous cells. Nearly 20 years ago, NK cell …

A pan-cancer single-cell panorama of human natural killer cells

F Tang, J Li, L Qi, D Liu, Y Bo, S Qin, Y Miao, K Yu… - Cell, 2023 - cell.com
Natural killer (NK) cells play indispensable roles in innate immune responses against tumor
progression. To depict their phenotypic and functional diversities in the tumor …

Interleukin-7 biology and its effects on immune cells: mediator of generation, differentiation, survival, and homeostasis

D Chen, TX Tang, H Deng, XP Yang… - Frontiers in …, 2021 - frontiersin.org
Interleukin-7 (IL-7), a molecule known for its growth-promoting effects on progenitors of B
cells, remains one of the most extensively studied cytokines. It plays a vital role in health …

Tissue determinants of human NK cell development, function, and residence

P Dogra, C Rancan, W Ma, M Toth, T Senda… - Cell, 2020 - cell.com
Immune responses in diverse tissue sites are critical for protective immunity and
homeostasis. Here, we investigate how tissue localization regulates the development and …

The broad spectrum of human natural killer cell diversity

AG Freud, BL Mundy-Bosse, J Yu, MA Caligiuri - Immunity, 2017 - cell.com
Natural killer (NK) cells provide protection against infectious pathogens and cancer. For
decades it has been appreciated that two major NK cell subsets (CD56 bright and CD56 …

Five decades of natural killer cell discovery

LL Lanier - Journal of Experimental Medicine, 2024 - rupress.org
The first descriptions of “non-specific” killing of tumor cells by lymphocytes were reported in
1973, and subsequently, the mediators of the activity were named “natural killer”(NK) cells …

Mechanisms of key innate immune cells in early-and late-onset preeclampsia

I Aneman, D Pienaar, S Suvakov, TP Simic… - Frontiers in …, 2020 - frontiersin.org
Preeclampsia is a complex cardiovascular disorder of pregnancy with underlying
multifactorial pathogeneses; however, its etiology is not fully understood. It is characterized …

Single-cell chromatin modification profiling reveals increased epigenetic variations with aging

P Cheung, F Vallania, HC Warsinske, M Donato… - Cell, 2018 - cell.com
Post-translational modifications of histone proteins and exchanges of histone variants of
chromatin are central to the regulation of nearly all DNA-templated biological processes …

NK cells and type 1 innate lymphoid cells: partners in host defense

H Spits, JH Bernink, L Lanier - Nature immunology, 2016 - nature.com
Innate lymphoid cells (ILCs) are effectors and regulators of innate immunity and tissue
modeling and repair. Researchers have identified subsets of ILCs with differing functional …