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Natural killer cell therapies
E Vivier, L Rebuffet, E Narni-Mancinelli, S Cornen… - Nature, 2024 - nature.com
Natural killer (NK) cells are lymphocytes of the innate immune system. A key feature of NK
cells is their ability to recognize a wide range of cells in distress, particularly tumour cells …
cells is their ability to recognize a wide range of cells in distress, particularly tumour cells …
Exploring the NK cell platform for cancer immunotherapy
JA Myers, JS Miller - Nature reviews Clinical oncology, 2021 - nature.com
Natural killer (NK) cells are cytotoxic lymphocytes of the innate immune system that are
capable of killing virally infected and/or cancerous cells. Nearly 20 years ago, NK cell …
capable of killing virally infected and/or cancerous cells. Nearly 20 years ago, NK cell …
A pan-cancer single-cell panorama of human natural killer cells
F Tang, J Li, L Qi, D Liu, Y Bo, S Qin, Y Miao, K Yu… - Cell, 2023 - cell.com
Natural killer (NK) cells play indispensable roles in innate immune responses against tumor
progression. To depict their phenotypic and functional diversities in the tumor …
progression. To depict their phenotypic and functional diversities in the tumor …
Interleukin-7 biology and its effects on immune cells: mediator of generation, differentiation, survival, and homeostasis
D Chen, TX Tang, H Deng, XP Yang… - Frontiers in …, 2021 - frontiersin.org
Interleukin-7 (IL-7), a molecule known for its growth-promoting effects on progenitors of B
cells, remains one of the most extensively studied cytokines. It plays a vital role in health …
cells, remains one of the most extensively studied cytokines. It plays a vital role in health …
Tissue determinants of human NK cell development, function, and residence
Immune responses in diverse tissue sites are critical for protective immunity and
homeostasis. Here, we investigate how tissue localization regulates the development and …
homeostasis. Here, we investigate how tissue localization regulates the development and …
The broad spectrum of human natural killer cell diversity
Natural killer (NK) cells provide protection against infectious pathogens and cancer. For
decades it has been appreciated that two major NK cell subsets (CD56 bright and CD56 …
decades it has been appreciated that two major NK cell subsets (CD56 bright and CD56 …
Five decades of natural killer cell discovery
LL Lanier - Journal of Experimental Medicine, 2024 - rupress.org
The first descriptions of “non-specific” killing of tumor cells by lymphocytes were reported in
1973, and subsequently, the mediators of the activity were named “natural killer”(NK) cells …
1973, and subsequently, the mediators of the activity were named “natural killer”(NK) cells …
Mechanisms of key innate immune cells in early-and late-onset preeclampsia
I Aneman, D Pienaar, S Suvakov, TP Simic… - Frontiers in …, 2020 - frontiersin.org
Preeclampsia is a complex cardiovascular disorder of pregnancy with underlying
multifactorial pathogeneses; however, its etiology is not fully understood. It is characterized …
multifactorial pathogeneses; however, its etiology is not fully understood. It is characterized …
Single-cell chromatin modification profiling reveals increased epigenetic variations with aging
Post-translational modifications of histone proteins and exchanges of histone variants of
chromatin are central to the regulation of nearly all DNA-templated biological processes …
chromatin are central to the regulation of nearly all DNA-templated biological processes …
NK cells and type 1 innate lymphoid cells: partners in host defense
Innate lymphoid cells (ILCs) are effectors and regulators of innate immunity and tissue
modeling and repair. Researchers have identified subsets of ILCs with differing functional …
modeling and repair. Researchers have identified subsets of ILCs with differing functional …