Gastrointestinal involvement in Parkinson's disease: pathophysiology, diagnosis, and management

T Warnecke, KH Schäfer, I Claus, K Del Tredici… - npj Parkinson's …, 2022 - nature.com
Growing evidence suggests an increasing significance for the extent of gastrointestinal tract
(GIT) dysfunction in Parkinson's disease (PD). Most patients suffer from GIT symptoms …

[HTML][HTML] Mammalian transient receptor potential TRPA1 channels: from structure to disease

K Talavera, JB Startek, J Alvarez-Collazo… - Physiological …, 2020 - journals.physiology.org
The transient receptor potential ankyrin (TRPA) channels are Ca 2+-permeable nonselective
cation channels remarkably conserved through the animal kingdom. Mammals have only …

[HTML][HTML] Mechanosensitive ion channels in apoptosis and ferroptosis: focusing on the role of Piezo1

YJ Kim, J Hyun - BMB reports, 2023 - ncbi.nlm.nih.gov
Mechanosensitive ion channels sense mechanical stimuli applied directly to the cellular
membranes or indirectly through their tethered components, provoking cellular …

Effects of capsaicin on swallowing function in stroke patients with dysphagia: a randomized controlled trial

Z Wang, L Wu, Q Fang, M Shen, L Zhang… - Journal of Stroke and …, 2019 - Elsevier
Abstract Background/Aims Dysphagia is a common complication after acute stroke. While
there are several innovative treatments being tested to improve the swallowing function of …

Short‐term neurophysiological effects of sensory pathway neurorehabilitation strategies on chronic poststroke oropharyngeal dysphagia

C Cabib, W Nascimento, L Rofes… - …, 2020 - Wiley Online Library
Background Neurorehabilitation strategies for chronic poststroke (PS) oropharyngeal
dysphagia (OD) have been mainly focused on the neurostimulation of the pharyngeal motor …

New natural agonists of the transient receptor potential Ankyrin 1 (TRPA1) channel

C Legrand, JM Merlini, C de Senarclens-Bezençon… - Scientific reports, 2020 - nature.com
The transient receptor potential (TRP) channels family are cationic channels involved in
various physiological processes as pain, inflammation, metabolism, swallowing function, gut …

[HTML][HTML] Effect of capsaicinoids on neurophysiological, biochemical, and mechanical parameters of swallowing function

S Suntrup-Krueger, P Muhle, I Kampe, P Egidi, T Ruck… - …, 2021 - Elsevier
Oropharyngeal dysphagia is prevalent in age-related neurological disorders presenting with
impaired efficacy and safety of swallowing due to a loss of muscle force and sensory deficits …

Acute and subacute effects of oropharyngeal sensory stimulation with TRPV1 agonists in older patients with oropharyngeal dysphagia: a biomechanical and …

N Tomsen, O Ortega, L Rofes… - Therapeutic …, 2019 - journals.sagepub.com
Background: Older people with oropharyngeal dysphagia (OD) present a decline in
pharyngeal sensory function. The aim of this proof-of-concept study was to assess the …

Oropharyngeal dysphagia in older people is associated with reduced pharyngeal sensitivity and low substance P and CGRP concentration in saliva

N Tomsen, O Ortega, W Nascimento, S Carrión… - Dysphagia, 2022 - Springer
Abstract Substance P (SP) and Calcitonine gene-related peptide (CGRP) are released by
sensory nerve fibers in the oropharynx. Patients with oropharyngeal dysphagia (OD) present …

Activation of TRPV1 and TRPM8 channels in the larynx and associated laryngopharyngeal regions facilitates the swallowing reflex

MZ Hossain, H Ando, S Unno, Y Masuda… - International journal of …, 2018 - mdpi.com
The larynx and associated laryngopharyngeal regions are innervated by the superior
laryngeal nerve (SLN) and are highly reflexogenic. Transient receptor potential (TRP) …