Physiology and pharmacology of the enteroendocrine hormone glucagon-like peptide-2
DJ Drucker, B Yusta - Annual review of physiology, 2014 - annualreviews.org
Glucagon-like peptide-2 (GLP-2) is a 33-amino-acid proglucagon-derived peptide secreted
from enteroendocrine L cells. GLP-2 circulates at low basal levels in the fasting period, and …
from enteroendocrine L cells. GLP-2 circulates at low basal levels in the fasting period, and …
Porcine models of digestive disease: the future of large animal translational research
There is increasing interest in nonrodent translational models for the study of human
disease. The pig, in particular, serves as a useful animal model for the study of …
disease. The pig, in particular, serves as a useful animal model for the study of …
Invited review: the preterm pig as a model in pediatric gastroenterology
At birth, the newborn mammal undergoes a transition from a sterile uterine environment with
a constant nutrient supply, to a microbe-rich environment with intermittent oral intake of …
a constant nutrient supply, to a microbe-rich environment with intermittent oral intake of …
Minireview: Glucagon-like peptides regulate cell proliferation and apoptosis in the pancreas, gut, and central nervous system
Gut peptides exert diverse effects regulating satiety, gastrointestinal motility and acid
secretion, epithelial integrity, and both nutrient absorption and disposal. These actions are …
secretion, epithelial integrity, and both nutrient absorption and disposal. These actions are …
Glucagon-like peptides: regulators of cell proliferation, differentiation, and apoptosis
DJ Drucker - Molecular endocrinology, 2003 - academic.oup.com
Peptide hormones are secreted from endocrine cells and neurons and exert their actions
through activation of G protein-coupled receptors to regulate a diverse number of …
through activation of G protein-coupled receptors to regulate a diverse number of …
Biological actions and therapeutic potential of the glucagon-like peptides
DJ Drucker - Gastroenterology, 2002 - Elsevier
The glucagon-like peptides (GLP-1 and GLP-2) are proglucagon-derived peptides
cosecreted from gut endocrine cells in response to nutrient ingestion. GLP-1 acts as an …
cosecreted from gut endocrine cells in response to nutrient ingestion. GLP-1 acts as an …
Glucagon-like peptide 2 stimulates glucagon secretion, enhances lipid absorption, and inhibits gastric acid secretion in humans
JJ Meier, MA Nauck, A Pott, K Heinze, O Goetze… - Gastroenterology, 2006 - Elsevier
Background & Aims: The gut-derived peptide glucagon-like peptide 2 (GLP-2) has been
suggested as a potential drug candidate for the treatment of various intestinal diseases …
suggested as a potential drug candidate for the treatment of various intestinal diseases …
GLP-2 receptor localizes to enteric neurons and endocrine cells expressing vasoactive peptides and mediates increased blood flow
X Guan, HE Karpen, J Stephens, JT Bukowski, S Niu… - Gastroenterology, 2006 - Elsevier
Background & Aims: Glucagon-like peptide-2 (GLP-2) is a nutrient-responsive hormone that
exerts diverse actions in the gastrointestinal tract, including enhancing epithelial cell survival …
exerts diverse actions in the gastrointestinal tract, including enhancing epithelial cell survival …
Gut responses to enteral nutrition in preterm infants and animals
PT Sangild - Experimental biology and medicine, 2006 - journals.sagepub.com
Preterm birth is associated with immature digestive function that may require the use of total
parenteral nutrition and special oral feeding regimens. Little is known about the responses …
parenteral nutrition and special oral feeding regimens. Little is known about the responses …
Intestinal morphology and enzymatic activity in newly weaned pigs fed contrasting fiber concentrations and fiber properties
The main objective of this study was to determine the effect of fiber source and concentration
on morphological characteristics, mucin staining pattern, and mucosal enzyme activities in …
on morphological characteristics, mucin staining pattern, and mucosal enzyme activities in …