Physiology and pharmacology of the enteroendocrine hormone glucagon-like peptide-2

DJ Drucker, B Yusta - Annual review of physiology, 2014 - annualreviews.org
Glucagon-like peptide-2 (GLP-2) is a 33-amino-acid proglucagon-derived peptide secreted
from enteroendocrine L cells. GLP-2 circulates at low basal levels in the fasting period, and …

Porcine models of digestive disease: the future of large animal translational research

LM Gonzalez, AJ Moeser, AT Blikslager - Translational research, 2015 - Elsevier
There is increasing interest in nonrodent translational models for the study of human
disease. The pig, in particular, serves as a useful animal model for the study of …

Invited review: the preterm pig as a model in pediatric gastroenterology

PT Sangild, T Thymann, M Schmidt… - Journal of animal …, 2013 - academic.oup.com
At birth, the newborn mammal undergoes a transition from a sterile uterine environment with
a constant nutrient supply, to a microbe-rich environment with intermittent oral intake of …

Minireview: Glucagon-like peptides regulate cell proliferation and apoptosis in the pancreas, gut, and central nervous system

PL Brubaker, DJ Drucker - Endocrinology, 2004 - academic.oup.com
Gut peptides exert diverse effects regulating satiety, gastrointestinal motility and acid
secretion, epithelial integrity, and both nutrient absorption and disposal. These actions are …

Glucagon-like peptides: regulators of cell proliferation, differentiation, and apoptosis

DJ Drucker - Molecular endocrinology, 2003 - academic.oup.com
Peptide hormones are secreted from endocrine cells and neurons and exert their actions
through activation of G protein-coupled receptors to regulate a diverse number of …

Biological actions and therapeutic potential of the glucagon-like peptides

DJ Drucker - Gastroenterology, 2002 - Elsevier
The glucagon-like peptides (GLP-1 and GLP-2) are proglucagon-derived peptides
cosecreted from gut endocrine cells in response to nutrient ingestion. GLP-1 acts as an …

Glucagon-like peptide 2 stimulates glucagon secretion, enhances lipid absorption, and inhibits gastric acid secretion in humans

JJ Meier, MA Nauck, A Pott, K Heinze, O Goetze… - Gastroenterology, 2006 - Elsevier
Background & Aims: The gut-derived peptide glucagon-like peptide 2 (GLP-2) has been
suggested as a potential drug candidate for the treatment of various intestinal diseases …

GLP-2 receptor localizes to enteric neurons and endocrine cells expressing vasoactive peptides and mediates increased blood flow

X Guan, HE Karpen, J Stephens, JT Bukowski, S Niu… - Gastroenterology, 2006 - Elsevier
Background & Aims: Glucagon-like peptide-2 (GLP-2) is a nutrient-responsive hormone that
exerts diverse actions in the gastrointestinal tract, including enhancing epithelial cell survival …

Gut responses to enteral nutrition in preterm infants and animals

PT Sangild - Experimental biology and medicine, 2006 - journals.sagepub.com
Preterm birth is associated with immature digestive function that may require the use of total
parenteral nutrition and special oral feeding regimens. Little is known about the responses …

Intestinal morphology and enzymatic activity in newly weaned pigs fed contrasting fiber concentrations and fiber properties

MS Hedemann, M Eskildsen, HN Lærke… - Journal of animal …, 2006 - academic.oup.com
The main objective of this study was to determine the effect of fiber source and concentration
on morphological characteristics, mucin staining pattern, and mucosal enzyme activities in …