Mitochondrial dysfunction: mechanisms and advances in therapy

Y Zong, H Li, P Liao, L Chen, Y Pan, Y Zheng… - Signal transduction and …, 2024 - nature.com
Mitochondria, with their intricate networks of functions and information processing, are
pivotal in both health regulation and disease progression. Particularly, mitochondrial …

[HTML][HTML] Mitochondria and brain disease: a comprehensive review of pathological mechanisms and therapeutic opportunities

VJ Clemente-Suárez, L Redondo-Flórez… - Biomedicines, 2023 - mdpi.com
Mitochondria play a vital role in maintaining cellular energy homeostasis, regulating
apoptosis, and controlling redox signaling. Dysfunction of mitochondria has been implicated …

N-Acetylcysteine (NAC): Impacts on Human Health

MCS Tenório, NG Graciliano, FA Moura, ACM Oliveira… - Antioxidants, 2021 - mdpi.com
N-acetylcysteine (NAC) is a medicine widely used to treat paracetamol overdose and as a
mucolytic compound. It has a well-established safety profile, and its toxicity is uncommon …

Species-specific FMRP regulation of RACK1 is critical for prenatal cortical development

M Shen, CL Sirois, Y Guo, M Li, Q Dong… - Neuron, 2023 - cell.com
Fragile X messenger ribonucleoprotein 1 protein (FMRP) deficiency leads to fragile X
syndrome (FXS), an autism spectrum disorder. The role of FMRP in prenatal human brain …

Insights into myelin dysfunction in schizophrenia and bipolar disorder

M Valdés-Tovar… - World Journal of …, 2022 - pmc.ncbi.nlm.nih.gov
Schizophrenia and bipolar disorder are disabling psychiatric disorders with a worldwide
prevalence of approximately 1%. Both disorders present chronic and deteriorating …

Anxiety and brain mitochondria: a bidirectional crosstalk

MD Filiou, C Sandi - Trends in neurosciences, 2019 - cell.com
Accumulating data highlight the contribution of brain mitochondria and bioenergetics to
psychiatric disorders and stress-related pathologies. Although anxiety has not received …

Identifying plasma metabolic characteristics of major depressive disorder, bipolar disorder, and schizophrenia in adolescents

B Yin, Y Cai, T Teng, X Wang, X Liu, X Li… - Translational …, 2024 - nature.com
Major depressive disorder (MDD), bipolar disorder (BD), and schizophrenia (SCZ) are
classified as major mental disorders and together account for the second-highest global …

Gut dysbiosis dysregulates central and systemic homeostasis via suboptimal mitochondrial function: assessment, treatment and classification implications

G Anderson, M Maes - Current Topics in Medicinal Chemistry, 2020 - ingentaconnect.com
The gut and mitochondria have emerged as two important hubs at the cutting edge of
research across a diverse array of medical conditions, including most psychiatric conditions …

Mitochondria DNA copy number, mitochondria DNA total somatic deletions, Complex I activity, synapse number, and synaptic mitochondria number are altered in …

SC Das, BE Hjelm, BL Rollins, A Sequeira… - Translational …, 2022 - nature.com
Mitochondrial dysfunction is a neurobiological phenomenon implicated in the
pathophysiology of schizophrenia and bipolar disorder that can synergistically affect …

Mitochondria in the central nervous system in health and disease: The puzzle of the therapeutic potential of mitochondrial transplantation

K Tripathi, D Ben-Shachar - Cells, 2024 - mdpi.com
Mitochondria, the energy suppliers of the cells, play a central role in a variety of cellular
processes essential for survival or leading to cell death. Consequently, mitochondrial …