Molecular genetics of bladder cancer: Emerging mechanisms of tumor initiation and progression
Urothelial cancer has served as one of the most important sources of information about the
mutational events that underlie the development of human solid malignancies. Although …
mutational events that underlie the development of human solid malignancies. Although …
[HTML][HTML] Promising pharmacological directions in the world of lysophosphatidic acid signaling
NC Stoddard, J Chun - Biomolecules & therapeutics, 2015 - ncbi.nlm.nih.gov
Lysophosphatidic acid (LPA) is a signaling lipid that binds to six known lysophosphatidic
acid receptors (LPARs), named LPA 1-LPA 6. These receptors initiate signaling cascades …
acid receptors (LPARs), named LPA 1-LPA 6. These receptors initiate signaling cascades …
Identification and characterization of a novel lysophosphatidic acid receptor, p2y5/LPA6
K Yanagida, K Masago, H Nakanishi, Y Kihara… - Journal of Biological …, 2009 - ASBMB
p2y5 is an orphan G protein-coupled receptor that is closely related to the fourth
lysophosphatidic acid (LPA) receptor, LPA 4. Here we report that p2y5 is a novel LPA …
lysophosphatidic acid (LPA) receptor, LPA 4. Here we report that p2y5 is a novel LPA …
Autotaxin–lysophosphatidic acid signaling in alzheimer's disease
The brain contains various forms of lipids that are important for maintaining its structural
integrity and regulating various signaling cascades. Autotaxin (ATX) is an ecto-nucleotide …
integrity and regulating various signaling cascades. Autotaxin (ATX) is an ecto-nucleotide …
A homozygous nonsense mutation in the human desmocollin-3 (DSC3) gene underlies hereditary hypotrichosis and recurrent skin vesicles
Desmosomes are the major players in epidermis and cardiac muscles and contribute to
intercellular binding and maintenance of tissue integrity. Two important constituents of …
intercellular binding and maintenance of tissue integrity. Two important constituents of …
Druggable lysophospholipid signaling pathways
K Yanagida, WJ Valentine - Druggable Lipid Signaling Pathways, 2020 - Springer
Lysophosphatidic acid (LPA) has major roles as a bioactive signaling molecule, with
multiple physiological and pathological roles being described in almost every major organ …
multiple physiological and pathological roles being described in almost every major organ …
A splice variant in KRT71 is associated with curly coat phenotype of Selkirk Rex cats
One of the salient features of the domestic cat is the aesthetics of its fur. The Selkirk Rex
breed is defined by an autosomal dominant woolly rexoid hair (ADWH) abnormality that is …
breed is defined by an autosomal dominant woolly rexoid hair (ADWH) abnormality that is …
Isolated autosomal recessive woolly hair/hypotrichosis: genetics, pathogenesis and therapies
M Akiyama - Journal of the European Academy of Dermatology …, 2021 - Wiley Online Library
Isolated autosomal recessive woolly hair/hypotrichosis (ARWH) is a rare hereditary hair
disease characterized by tightly curled sparse hair at birth or in early infancy. Patients with …
disease characterized by tightly curled sparse hair at birth or in early infancy. Patients with …
To the root of the curl: a signature of a recent selective sweep identifies a mutation that defines the Cornish Rex cat breed
The cat (Felis silvestris catus) shows significant variation in pelage, morphological, and
behavioral phenotypes amongst its over 40 domesticated breeds. The majority of the breed …
behavioral phenotypes amongst its over 40 domesticated breeds. The majority of the breed …
Novel mutations in the keratin-74 (KRT74) gene underlie autosomal dominant woolly hair/hypotrichosis in Pakistani families
Autosomal dominant woolly hair (ADWH) is an inherited condition of tightly curled and
twisted scalp hair. Recently, a mutation in human keratin-74 (KRT74) gene has been shown …
twisted scalp hair. Recently, a mutation in human keratin-74 (KRT74) gene has been shown …