The complement system is important for cellular integrity and tissue homeostasis.
Complement activation mediates the removal of microorganisms and the clearance of …

The complement system plays crucial roles in a wide breadth of immune and inflammatory
processes and is frequently cited as an etiological or aggravating factor in many human …

The recent outbreak of mpox epidemic, caused by monkeypox virus (MPXV), poses a new
threat to global public health. Here, we initially assessed the preexisting antibody level to the …

The past few years have proven to be a highly successful and exciting period for the field of
complement-directed drug discovery and development. Driven by promising experiences …

Atypical hemolytic uremic syndrome (aHUS) is a disease of hemolytic anemia,
thrombocytopenia, and renal failure associated with defective alternative pathway (AP) …

The complement inhibitor Factor H has three distinct binding sites for C3b and for heparin,
but in solution uses specifically the most C-terminal domain, ie short consensus repeats …

The secreted Staphylococcus aureus extracellular fibrinogen-binding protein (Efb) is a
virulence factor that binds to both the complement component C3b and fibrinogen. Our …

The anionic polysaccharides heparin and heparan sulphate play essential roles in the
regulation of many physiological processes. Heparin is often used as an analogue for …

Atypical hemolytic uremic syndrome is a disease that is characterized by microangiopathic
hemolytic anemia, thrombocytopenia, and acute renal failure. Mutations in the complement …

Small angle scattering can provide unique structural information on the shape, domain
organisation, and interactions of biomacromolecules in solution. Small angle neutron …