Targeting apoptosis in cancer therapy
For over three decades, a mainstay and goal of clinical oncology has been the development
of therapies promoting the effective elimination of cancer cells by apoptosis. This …
of therapies promoting the effective elimination of cancer cells by apoptosis. This …
Harnessing TRAIL-induced cell death for cancer therapy: a long walk with thrilling discoveries
A Montinaro, H Walczak - Cell Death & Differentiation, 2023 - nature.com
Tumor necrosis factor (TNF)-related apoptosis inducing ligand (TRAIL) can induce apoptosis
in a wide variety of cancer cells, both in vitro and in vivo, importantly without killing any …
in a wide variety of cancer cells, both in vitro and in vivo, importantly without killing any …
Exploring the TRAILs less travelled: TRAIL in cancer biology and therapy
S Von Karstedt, A Montinaro, H Walczak - Nature Reviews Cancer, 2017 - nature.com
The discovery that the tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) can
induce apoptosis of cancer cells without causing toxicity in mice has led to the in-depth study …
induce apoptosis of cancer cells without causing toxicity in mice has led to the in-depth study …
Structural principles of tumor necrosis factor superfamily signaling
ÉS Vanamee, DL Faustman - Science signaling, 2018 - science.org
The tumor necrosis factor (TNF) ligand and receptor superfamilies play an important role in
cell proliferation, survival, and death. Stimulating or inhibiting TNF superfamily signaling …
cell proliferation, survival, and death. Stimulating or inhibiting TNF superfamily signaling …
Getting TRAIL back on track for cancer therapy
JV Lemke, S von Karstedt, J Zinngrebe… - Cell Death & …, 2014 - nature.com
Unlike other members of the TNF superfamily, the TNF-related apoptosis-inducing ligand
(TRAIL, also known as Apo2L) possesses the unique capacity to induce apoptosis …
(TRAIL, also known as Apo2L) possesses the unique capacity to induce apoptosis …
Death receptors: signaling and modulation
REVIEW Apoptosis is a cell suicide mechanism that enables metazoans to control cell
number in tissues and to eliminate individual cells that threaten the animal's survival. Certain …
number in tissues and to eliminate individual cells that threaten the animal's survival. Certain …
Tumoricidal activity of tumor necrosis factor–related apoptosis–inducing ligand in vivo
H Walczak, RE Miller, K Ariail, B Gliniak, TS Griffith… - Nature medicine, 1999 - nature.com
To evaluate the utility of tumor necrosis factor–related apoptosis–inducing ligand (TRAIL) as
a cancer therapeutic, we created leucine zipper (LZ) forms of human (hu) and murine (mu) …
a cancer therapeutic, we created leucine zipper (LZ) forms of human (hu) and murine (mu) …
Biochemical pathways of caspase activation during apoptosis
I Budihardjo, H Oliver, M Lutter, X Luo… - Annual review of cell …, 1999 - annualreviews.org
▪ Abstract Caspase activation plays a central role in the execution of apoptosis. The key
components of the biochemical pathways of caspase activation have been recently …
components of the biochemical pathways of caspase activation have been recently …
Safety and antitumor activity of recombinant soluble Apo2 ligand
A Ashkenazi, RC Pai, S Fong, S Leung… - The Journal of …, 1999 - Am Soc Clin Investig
TNF and Fas ligand induce apoptosis in tumor cells; however, their severe toxicity toward
normal tissues hampers their application to cancer therapy. Apo2 ligand (Apo2L, or TRAIL) …
normal tissues hampers their application to cancer therapy. Apo2 ligand (Apo2L, or TRAIL) …
Targeting death and decoy receptors of the tumour-necrosis factor superfamily
A Ashkenazi - Nature Reviews Cancer, 2002 - nature.com
Cancer cells often develop resistance to chemotherapy or irradiation through mutations in
the p53 tumour-suppressor gene, which prevent apoptosis induction in response to cellular …
the p53 tumour-suppressor gene, which prevent apoptosis induction in response to cellular …