[HTML][HTML] Engineered M13 phage as a novel therapeutic bionanomaterial for clinical applications: From tissue regeneration to cancer therapy

C Chang, W Guo, X Yu, C Guo, N Zhou, X Guo… - Materials Today Bio, 2023 - Elsevier
Bacteriophages (phages) are nanostructured viruses with highly selective antibacterial
properties that have gained attention beyond eliminating bacteria. Specifically, M13 phages …

Bioengineered human skeletal muscle capable of functional regeneration

JW Fleming, AJ Capel, RP Rimington, P Wheeler… - BMC biology, 2020 - Springer
Abstract Background Skeletal muscle (SkM) regenerates following injury, replacing
damaged tissue with high fidelity. However, in serious injuries, non-regenerative defects …

Ginkgolide B facilitates muscle regeneration via rejuvenating osteocalcin‐mediated bone‐to‐muscle modulation in aged mice

BYH Wang, YF Chen, AWT Hsiao… - Journal of Cachexia …, 2023 - Wiley Online Library
Background The progressive deterioration of tissue–tissue crosstalk with aging causes a
striking impairment of tissue homeostasis and functionality, particularly in the …

Bioengineered model of the human motor unit with physiologically functional neuromuscular junctions

RP Rimington, JW Fleming, AJ Capel, PC Wheeler… - Scientific Reports, 2021 - nature.com
Investigations of the human neuromuscular junction (NMJ) have predominately utilised
experimental animals, model organisms, or monolayer cell cultures that fail to represent the …

[HTML][HTML] Topography-mediated myotube and endothelial alignment, differentiation, and extracellular matrix organization for skeletal muscle engineering

AM Almonacid Suarez, MGL Brinker, LA Brouwer… - Polymers, 2020 - mdpi.com
Understanding the response of endothelial cells to aligned myotubes is important to create
an appropriate environment for tissue-engineered vascularized skeletal muscle. Part of the …

Spatiotemporal single-cell tracking analysis in 3D tissues to reveal heterogeneous cellular response to mechanical stimuli

K Kasahara, J Muramatsu, Y Kurashina, S Miura… - Science …, 2023 - science.org
Mechanical stimuli have been recognized as important for tissue maturation, homeostasis
and constructing engineered three-dimensional (3D) tissues. However, we know little about …

Modelling Skeletal Muscle Ageing and Repair In Vitro

J Tarum, H Degens, MD Turner… - Journal of Tissue …, 2023 - Wiley Online Library
Healthy skeletal muscle can regenerate after ischaemic, mechanical, or toxin‐induced
injury, but ageing impairs that regeneration potential. This has been largely attributed to …

A concise in vitro model for evaluating interactions between macrophage and skeletal muscle cells during muscle regeneration

N Kase, Y Kitagawa, A Ikenaka, A Niwa… - Frontiers in Cell and …, 2023 - frontiersin.org
Skeletal muscle has a highly regenerative capacity, but the detailed process is not fully
understood. Several in vitro skeletal muscle regeneration models have been developed to …

Critical-Size Defect Tibialis Anterior (TA) Muscle Regeneration using Ex-Vivo Mice Hindlimbs Culturing under Dynamic Mechanical Loading

D Jacho, J Huynh, E Crowe, A Rabino, M Yildirim… - bioRxiv, 2024 - biorxiv.org
In this study, we introduced an innovative computer-controlled ex vivo mice hindlimb
culturing platform operating under dynamic loading, coupled with injectable cell-laden …

Development of Skeletal Muscle Models to Study Ageing and Associated Conditions

J Tarum - 2023 - search.proquest.com
Rapid ageing of the population together with raised prevalence of chronic metabolic
diseases provokes huge economic burden on healthcare systems. Furthermore, age-related …