Tissue-resident macrophages adapt to local signals within tissues to acquire specific
functions. Neoplasia transforms the tissue, raising the question as to how the environmental …

Tooth enamel secreted by ameloblasts (AMs) is the hardest material in the human body,
acting as a shield to protect the teeth. However, the enamel is gradually damaged or …

CD8+ T cells provide host protection against pathogens by differentiating into distinct
effector and memory cell subsets, but how chromatin is site-specifically remodeled during …

The peripheral nervous system harbors a remarkable potential to regenerate after acute
nerve trauma. Full functional recovery, however, is rare and critically depends on peripheral …

Aneuploidy, the presence of chromosome gains or losses, is a hallmark of cancer. Here, we
describe KaryoCreate (karyotype CRISPR-engineered aneuploidy technology), a system …

Summary The Long-Read Personalized OncoGenomics (POG) dataset comprises a cohort
of 189 patient tumors and 41 matched normal samples sequenced using the Oxford …

Contacts between enhancers and promoters are thought to relate to their ability to activate
transcription. Investigating factors that contribute to such chromatin interactions is therefore …

Deregulated inflammation is a critical feature driving the progression of tumors harboring
mutations in the liver kinase B1 (LKB1), yet the mechanisms linking LKB1 mutations to …

Hox transcription factors play crucial roles in organizing developmental patterning across
metazoa, but how these factors trigger regional morphogenesis has largely remained a …

Alterations in extracellular matrix (ECM) architecture and stiffness represent hallmarks of
cancer. Whether the biomechanical property of ECM impacts the functionality of tumor …