Availability of key nutrients, such as sugars, amino acids, and nitrogen compounds, dictates
the developmental programs and the growth rates of yeast cells. A number of overlap** …

The Atg1/ULK1 complex plays a central role in starvation-induced autophagy, integrating
signals from upstream sensors such as MTOR and AMPK and transducing them to the …

Protein phosphorylation is one of the most widespread post-translational modifications in
biology,. With advances in mass-spectrometry-based phosphoproteomics, 90,000 sites of …

The mammalian target of rapamycin (mTOR) protein kinase is a master growth promoter that
nucleates two complexes, mTORC1 and mTORC2. Despite the diverse processes controlled …

Phase separation can concentrate biomolecules and accelerate reactions. However, the
mechanisms and principles connecting this mesoscale organization to signaling dynamics …

Mass spectrometry has enabled the study of cellular signaling on a systems-wide scale,
through the quantification of post-translational modifications, such as protein …

It has long been axiomatic that a protein's structure determines its function. Intrinsically
disordered proteins (IDPs) and disordered protein regions (IDRs) defy this structure …

Introduction The mechanistic target of rapamycin (mTOR) complex 1 (mTORC1) protein
kinase promotes cell growth by controlling major anabolic and catabolic processes in …

The existence of extracellular phosphoproteins has been acknowledged for over a century.
However, research in this area has been undeveloped largely because the kinases that …

Protein post‐translational modifications (PTM s) allow the cell to regulate protein activity and
play a crucial role in the response to changes in external conditions or internal states …