Network science is today established as a backbone for description of structure and function
of various physical, chemical, biological, technological, and social systems. Here we review …

Histological analysis of donor pancreases coupled with measurement of serum C-peptide in
clinical cohorts has challenged the idea that all beta cells are eventually destroyed in type 1 …

Aims/hypothesis We hypothesised that human beta cells are structurally and functional
polarised with respect to the islet capillaries. We set out to test this using confocal …

Type 1 diabetes is an insulin-dependent, autoimmune disease where the pancreatic β cells
are destroyed resulting in hyperglycemia. This multifactorial disease involves multiple …

In commemoration of 100 years since the discovery of glucagon, we review current
knowledge about the human α cell. Alpha cells make up 30–40% of human islet endocrine …

The Centers for Disease Control and Prevention (CDC) provides extensive data that indicate
our need for drugs to maintain human population health. Despite the substantial availability …

Cellular and organism survival depends upon the regulation of pH, which is regulated by
highly specialized cell membrane transporters, the solute carriers (SLC)(For a …

Dysregulation of glucagon secretion in type 1 diabetes (T1D) involves hypersecretion during
postprandial states, but insufficient secretion during hypoglycemia. The sympathetic nervous …

Aims/hypothesis The molecular response and function of pancreatic islet cells during
metabolic stress is a complex process. The anatomical location and small size of pancreatic …

Glucagon is the principal glucose-elevating hormone that forms the first-line defence against
hypoglycaemia. Along with insulin, glucagon also plays a key role in maintaining systemic …