Background Anti-cancer therapy is often a cause of premature ovarian insufficiency and
infertility since the ovarian follicle reserve is extremely sensitive to the effects of …

Cancer treatments are increasingly effective, but can result in iatrogenic premature ovarian
insufficiency. Ovarian tissue cryopreservation is the only option available to preserve fertility …

Cancer treatment, such as chemotherapy, induces early ovarian follicular depletion and
subsequent infertility. In order to protect gametes from the gonadotoxic effects of …

STUDY QUESTION What are the effects of cyclophosphamide exposure on the human ovary
and can anti-Mullerian hormone (AMH) and rapamycin protect against these? SUMMARY …

Cyclophosphamide (CTX) has been broadly used in the clinic for the treatment of
autoimmune disorders and ovarian cancer. The process of chemotherapy has significant …

Among the investigated mechanisms of chemotherapy-induced damage to human
primordial follicle reserve are induction of DNA double-strand breaks (DSBs) and resultant …

Gonadotoxic treatments like chemotherapy or radiotherapy and ovarian surgery may result
in an accelerated depletion of the ovarian reserve and subsequent premature ovarian …

Incomplete spiral artery remodeling, caused by impaired extravillous trophoblast invasion, is
a fundamental pathogenic process associated with malplacentation and the development of …

Poly-ADP-ribose polymerase (PARP) plays an important role in DNA damage detection and
repair. PARP inhibitors (PARPi) are a novel class of targeted agents used widely in the …

Cyclophosphamide (CPM), a part of most cancer treatment regimens, has demonstrated
high gonadal toxicity in females. Initially, CPM is believed to damage the ovarian reserve by …