Apoptosis deregulation and the development of cancer multi-drug resistance
Simple Summary Despite recent therapeutic advances against cancer, many patients do not
respond well or respond poorly, to treatment and develop resistance to more than one anti …
respond well or respond poorly, to treatment and develop resistance to more than one anti …
Mechanisms underlying acute protection from cardiac ischemia-reperfusion injury
E Murphy, C Steenbergen - Physiological reviews, 2008 - journals.physiology.org
Mitochondria play an important role in cell death and cardioprotection. During ischemia,
when ATP is progressively depleted, ion pumps cannot function resulting in a rise in calcium …
when ATP is progressively depleted, ion pumps cannot function resulting in a rise in calcium …
The role of PI3K/Akt and ERK in neurodegenerative disorders
Abstract Disruption of Akt and Erk-mediated signal transduction significantly contributes in
the pathogenesis of various neurodegenerative diseases (NDs), such as Parkinson's …
the pathogenesis of various neurodegenerative diseases (NDs), such as Parkinson's …
NADPH oxidase-mediated redox signaling: roles in cellular stress response, stress tolerance, and tissue repair
F Jiang, Y Zhang, GJ Dusting, DR Sibley - Pharmacological reviews, 2011 - Elsevier
NADPH oxidase (Nox) has a dedicated function of generating reactive oxygen species
(ROS). Accumulating evidence suggests that Nox has an important role in signal …
(ROS). Accumulating evidence suggests that Nox has an important role in signal …
Anticancer properties of essential oils and other natural products
K Blowman, M Magalhães, MFL Lemos… - Evidence‐Based …, 2018 - Wiley Online Library
Essential oils are secondary metabolites with a key‐role in plants protection, consisting
primarily of terpenes with a volatile nature and a diverse array of chemical structures …
primarily of terpenes with a volatile nature and a diverse array of chemical structures …
Deletion of skeletal muscle Akt1/2 causes osteosarcopenia and reduces lifespan in mice
T Sasako, T Umehara, K Soeda, K Kaneko… - Nature …, 2022 - nature.com
Aging is considered to be accelerated by insulin signaling in lower organisms, but it
remained unclear whether this could hold true for mammals. Here we show that mice with …
remained unclear whether this could hold true for mammals. Here we show that mice with …
Understanding cancer and the anticancer activities of naphthoquinones–a review
KW Wellington - RSC advances, 2015 - pubs.rsc.org
The non-communicable disease, cancer, is one of the major causes of death across the
world and is forecast to increase by 75% to reach close to 25 million cases over the next two …
world and is forecast to increase by 75% to reach close to 25 million cases over the next two …
Lipotoxic lethal and sublethal stress signaling in hepatocytes: relevance to NASH pathogenesis [S]
The accumulation of lipids is a histologic and biochemical hallmark of obesity-associated
nonalcoholic fatty liver disease (NAFLD). A subset of NALFD patients develops progressive …
nonalcoholic fatty liver disease (NAFLD). A subset of NALFD patients develops progressive …
Novel function of keratins 5 and 14 in proliferation and differentiation of stratified epithelial cells
Keratins are cytoplasmic intermediate filament proteins preferentially expressed by epithelial
tissues in a site-specific and differentiation-dependent manner. The complex network of …
tissues in a site-specific and differentiation-dependent manner. The complex network of …
Inositol pyrophosphates inhibit Akt signaling, thereby regulating insulin sensitivity and weight gain
Summary The inositol pyrophosphate IP7 (5-diphosphoinositolpentakisphosphate), formed
by a family of three inositol hexakisphosphate kinases (IP6Ks), modulates diverse cellular …
by a family of three inositol hexakisphosphate kinases (IP6Ks), modulates diverse cellular …