Inflammatory responses play pivotal roles in cancer development, including tumor initiation,
promotion, progression, and metastasis. Cytokines are now recognized as important …

Most chronic diseases—such as cancer, cardiovascular disease (CVD), Alzheimer disease,
Parkinson disease, arthritis, diabetes and obesity—are becoming leading causes of …

The androgen receptor (AR) regulates prostate cell growth in man, and prostate cancer is
the commonest cancer in men in the UK. We present a comprehensive analysis of AR …

Studies in the past few years have provided compelling evidence for the critical role of
aberrant Signal Transducer and Activator of Transcription 3 (STAT3) in malignant …

Accumulated studies have provided controversial evidences of the association between
signal transducer and activator of transcription proteins 3 (STAT3) expression and survival of …

Abstract Reduction-oxidation factor 1-apurinic/apyrimidinic endonuclease (Ref-1/APE1) is a
critical node in tumor cells, both as a redox regulator of transcription factor activation and as …

The relationship between the cells that initiate cancer and the cancer stem-like cells that
propagate tumors has been poorly defined. In a human prostate tissue transformation …

Androgen deprivation therapy or ADT is one of the cornerstones of management of locally
advanced or metastatic prostate cancer, alongside radiation therapy. However, despite early …

As an established mediator of inflammation, interleukin-6 (IL-6) is implicated to facilitate
prostate cancer progression to androgen independence through transactivation of the …

The cells of the prostate gland are dependent on cell signaling pathways to regulate their
growth, maintenance and function. However, perturbations in key signaling pathways …