Alterations in the regulation of gene expression are frequently associated with
developmental diseases or cancer. Transcription activation is a key phenomenon in the …

Androgens and androgen receptors (AR) play a pivotal role in expression of the male
phenotype. Several diseases, such as androgen insensitivity syndrome (AIS) and prostate …

Eukaryotic gene transcription is accompanied by acetylation and methylation of
nucleosomes near promoters, but the locations and roles of histone modifications elsewhere …

The human body is composed of diverse cell types with distinct functions. Although it is
known that lineage specification depends on cell-specific gene expression, which in turn is …

Networks of regulatory enhancers dictate distinct cell identities and cellular responses to
diverse signals by instructing precise spatiotemporal patterns of gene expression. However …

Despite advances in prostate cancer diagnosis and management, morbidity from prostate
cancer remains high. Approximately 20% of men present with advanced or metastatic …

Although recent studies have indicated roles of long non-coding RNAs (lncRNAs) in
physiological aspects of cell-type determination and tissue homeostasis, their potential …

The evolution of prostate cancer from an androgen-dependent state to one that is androgen-
independent marks its lethal progression. The androgen receptor (AR) is essential in both …

Acetylation of histone H3 at lysine 27 is a well-defined marker of enhancer activity. However,
the functional impact of this modification at enhancers is poorly understood. Here, we use a …

Continued reliance on the androgen receptor (AR) is now understood as a core mechanism
in castration-resistant prostate cancer (CRPC), the most advanced form of this disease …